Mind the GAP: Wnt steps onto the mTORC1 train. uri icon

Overview

abstract

  • The TSC1/2 tumor-suppressor complex controls protein synthesis through the regulation of mTOR. In this issue of Cell, Inoki et al. (2006) report that the kinases GSK3 and AMPK cooperate in the activation of TSC2 to inhibit mTOR activity. Surprisingly, the phosphorylation of TSC2 by GSK3 is markedly suppressed by Wnt signaling. This suggests that components of the mTOR pathway may be therapeutic targets for diseases linked to hyperactive Wnt signaling.

publication date

  • September 8, 2006

Research

keywords

  • GTPase-Activating Proteins
  • Glycogen Synthase Kinase 3
  • Multiprotein Complexes
  • Signal Transduction
  • Tumor Suppressor Proteins
  • Wnt Proteins

Identity

Scopus Document Identifier

  • 33748168778

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2006.08.025

PubMed ID

  • 16959561

Additional Document Info

volume

  • 126

issue

  • 5