Signal integration and diversification through the p62 scaffold protein. Review uri icon

Overview

abstract

  • Signal specificity of multifunctional enzymes is achieved through protein-protein interactions involving specific domains on scaffold proteins. p62 (also known as sequestosome 1) is such a scaffold protein that possesses PB1 and UBA domains, and the TRAF6 binding sequence. Proteins recruited to these domains enable p62 to integrate kinase-activated and ubiquitin-mediated signaling pathways. The biological function of p62 has been studied in diverse systems and processes such as osteoclastogenesis, inflammation, differentiation, neurotrophin biology and obesity. The availability of mice in which p62 has been genetically inactivated is providing new insight into the mechanism and function of p62 at a whole-organism level.

publication date

  • December 15, 2006

Research

keywords

  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • Signal Transduction

Identity

Scopus Document Identifier

  • 33846692198

Digital Object Identifier (DOI)

  • 10.1016/j.tibs.2006.12.002

PubMed ID

  • 17174552

Additional Document Info

volume

  • 32

issue

  • 2