Function and translational regulation of mRNA in developing axons. Review uri icon

Overview

abstract

  • The capacity to synthesize proteins in axons is limited to early stages of neuronal development, while axons are undergoing elongation and pathfinding. Although the roles of local protein synthesis are not fully understood, it has been implicated in regulating the morphological plasticity of growth cones. Recent studies have identified specific mRNAs that are translated in growth cones in response to specific extracellular signals. In this review, we discuss the functional relevance of axonal protein translation for developing axons, the differences in translational capacity between developing and mature vertebrate axons, and possible pathways governing the specific translational activation of axonal mRNAs.

publication date

  • February 1, 2007

Research

keywords

  • Axons
  • Protein Biosynthesis
  • RNA, Messenger

Identity

PubMed Central ID

  • PMC3153311

Scopus Document Identifier

  • 34248561778

Digital Object Identifier (DOI)

  • 10.1016/j.semcdb.2007.01.003

PubMed ID

  • 17478114

Additional Document Info

volume

  • 18

issue

  • 2