Jaffrey, Samie R

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selected publications

Intricate 3D architecture of a DNA mimic of GFP. Nature. 2023 Academic Article GET IT
Times cited: 12
Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture. Nature communications. 2023 Academic Article GET IT
Author Correction: Transcriptional regulation of N⁶-methyladenosine orchestrates sex-dimorphic metabolic traits. Nature metabolism. 2023 Article GET IT
mRNA ageing shapes the Cap2 methylome in mammalian mRNA. Nature. 2023 Academic Article GET IT
Times cited: 2
BTG1 mutation yields supercompetitive B cells primed for malignant transformation. Science (New York, N.Y.). 2023 Academic Article GET IT
Designing and Expressing Circular RNA Aptamers to Regulate Mammalian Cell Biology. Methods in molecular biology (Clifton, N.J.). 2023 Academic Article GET IT
Synthetic biology tools to promote the folding and function of RNA aptamers in mammalian cells. RNA biology. 2023 Academic Article GET IT
Cbln1 regulates axon growth and guidance in multiple neural regions. PLoS biology. 2022 Academic Article GET IT
Times cited: 2
Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N ⁶-Methyladenosine-Modified RNAs. ACS pharmacology & translational science. 2022 Academic Article GET IT
Times cited: 2
Expanding the epitranscriptome: Dihydrouridine in mRNA. PLoS biology. 2022 Comment GET IT
Times cited: 1
Alphaherpesvirus US3 protein-mediated inhibition of the m6A mRNA methyltransferase complex. Cell reports. 2022 Academic Article GET IT
Times cited: 3
Alternative splicing of METTL3 explains apparently METTL3-independent m6A modifications in mRNA. PLoS biology. 2022 Academic Article GET IT
Times cited: 11
Author Correction: Transcriptional regulation of N⁶-methyladenosine orchestrates sex-dimorphic metabolic traits. Nature metabolism. 2022 Article GET IT
Hidden codes in mRNA: Control of gene expression by m⁶A. Molecular cell. 2022 Review GET IT
Times cited: 29
Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome. Nature immunology. 2022 Academic Article GET IT
Times cited: 21
N⁶-methyladenosine in poly(A) tails stabilize VSG transcripts. Nature. 2022 Academic Article GET IT
Times cited: 14
Detection of SARS-CoV-2 RNA Using a DNA Aptamer Mimic of Green Fluorescent Protein. ACS chemical biology. 2022 Academic Article GET IT
Times cited: 5
Self-Assembly of Intracellular Multivalent RNA Complexes Using Dimeric Corn and Beetroot Aptamers. Journal of the American Chemical Society. 2022 Academic Article GET IT
Times cited: 6
Publisher Correction: Repurposing an adenine riboswitch into a fluorogenic imaging and sensing tag. Nature chemical biology. 2022 Article GET IT
YTHDC2 control of gametogenesis requires helicase activity but not m⁶A binding. Genes & development. 2022 Academic Article GET IT
Times cited: 12
Repurposing an adenine riboswitch into a fluorogenic imaging and sensing tag. Nature chemical biology. 2021 Academic Article GET IT
Times cited: 22
The fluorescent aptamer Squash extensively repurposes the adenine riboswitch fold. Nature chemical biology. 2021 Academic Article GET IT
Times cited: 6
Noncoding RNAs: biology and applications-a Keystone Symposia report. Annals of the New York Academy of Sciences. 2021 Review GET IT
Times cited: 5
Engineering Fluorophore Recycling in a Fluorogenic RNA Aptamer. Angewandte Chemie (International ed. in English). 2021 Academic Article GET IT
Times cited: 9
Transcriptional regulation of N⁶-methyladenosine orchestrates sex-dimorphic metabolic traits. Nature metabolism. 2021 Academic Article GET IT
Times cited: 14
Mapping of m⁶A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-Low Induction of Therapy Resistance. Molecular cancer research : MCR. 2021 Academic Article GET IT
Times cited: 12
N⁶-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cancer cell. 2021 Academic Article GET IT
Times cited: 68
Naturally occurring three-way junctions can be repurposed as genetically encoded RNA-based sensors. Cell chemical biology. 2021 Academic Article GET IT
Times cited: 7
Trans ligation of RNAs to generate hybrid circular RNAs using highly efficient autocatalytic transcripts. Methods (San Diego, Calif.). 2021 Academic Article GET IT
Times cited: 3
mTORC1 promotes cell growth via m⁶A-dependent mRNA degradation. Molecular cell. 2021 Academic Article GET IT
Times cited: 31
Caspase-8 Inhibition Prevents the Cleavage and Degradation of E3 Ligase Substrate Receptor Cereblon and Potentiates Its Biological Function. Frontiers in cell and developmental biology. 2020 Academic Article GET IT
Times cited: 3
The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells. Cancer discovery. 2020 Academic Article GET IT
Times cited: 158
m6A RNA methylation impacts fate choices during skin morphogenesis. eLife. 2020 Academic Article GET IT
Times cited: 17
Imaging mRNA trafficking in living cells using fluorogenic proteins. Current opinion in chemical biology. 2020 Review GET IT
Times cited: 12
Imaging Intracellular S-Adenosyl Methionine Dynamics in Live Mammalian Cells with a Genetically Encoded Red Fluorescent RNA-Based Sensor. Journal of the American Chemical Society. 2020 Academic Article GET IT
Times cited: 32
A Unified Model for the Function of YTHDF Proteins in Regulating m⁶A-Modified mRNA. Cell. 2020 Academic Article GET IT
Times cited: 282
Limits in the detection of m⁶A changes using MeRIP/m⁶A-seq. Scientific reports. 2020 Academic Article GET IT
Times cited: 94
Fluorophore-Promoted RNA Folding and Photostability Enables Imaging of Single Broccoli-Tagged mRNAs in Live Mammalian Cells. Angewandte Chemie (International ed. in English). 2020 Academic Article GET IT
Times cited: 45
Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA. Nucleic acids research. 2019 Academic Article GET IT
Times cited: 81
Antibody cross-reactivity accounts for widespread appearance of m¹A in 5'UTRs. Nature communications. 2019 Academic Article GET IT
Times cited: 56
A Fluorogenic RNA-Based Sensor Activated by Metabolite-Induced RNA Dimerization. Cell chemical biology. 2019 Academic Article GET IT
Times cited: 21
Reading, writing and erasing mRNA methylation. Nature reviews. Molecular cell biology. 2019 Review GET IT
Times cited: 945
The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. Nucleic acids research. 2019 Academic Article GET IT
Times cited: 238
Live imaging of mRNA using RNA-stabilized fluorogenic proteins. Nature methods. 2019 Academic Article GET IT
Times cited: 52
RIBOTACs: Small Molecules Target RNA for Degradation. Cell chemical biology. 2019 Comment GET IT
Times cited: 23
m⁶A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment. Cell reports. 2019 Academic Article GET IT
Times cited: 86
Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons. Cell reports. 2019 Academic Article GET IT
Times cited: 17
m⁶A enhances the phase separation potential of mRNA. Nature. 2019 Academic Article GET IT
Times cited: 328
Identification of the m⁶Am Methyltransferase PCIF1 Reveals the Location and Functions of m⁶Am in the Transcriptome. Molecular cell. 2019 Academic Article GET IT
Times cited: 126
Discovering and Mapping the Modified Nucleotides That Comprise the Epitranscriptome of mRNA. Cold Spring Harbor perspectives in biology. 2019 Review GET IT
Times cited: 40
Combining Chemical Synthesis and Enzymatic Methylation to Access Short RNAs with Various 5' Caps. Chembiochem : a European journal of chemical biology. 2019 Academic Article GET IT
Times cited: 5
Highly efficient expression of circular RNA aptamers in cells using autocatalytic transcripts. Nature biotechnology. 2019 Academic Article GET IT
Times cited: 134
Transcriptome-Wide Mapping of m⁶ A and m⁶ Am at Single-Nucleotide Resolution Using miCLIP. Current protocols in molecular biology. 2019 Academic Article GET IT
Times cited: 16
Spectral Tuning by a Single Nucleotide Controls the Fluorescence Properties of a Fluorogenic Aptamer. Biochemistry. 2019 Academic Article GET IT
Times cited: 15
FTO controls reversible m⁶Am RNA methylation during snRNA biogenesis. Nature chemical biology. 2019 Academic Article GET IT
Times cited: 154
Detection of Low-Abundance Metabolites in Live Cells Using an RNA Integrator. Cell chemical biology. 2019 Academic Article GET IT
Times cited: 28
Nonsense-mediated RNA decay in the brain: emerging modulator of neural development and disease. Nature reviews. Neuroscience. 2018 Review GET IT
Times cited: 71
FTO, m⁶ A_m , and the hypothesis of reversible epitranscriptomic mRNA modifications. FEBS letters. 2018 Review GET IT
Times cited: 63
Distinguishing RNA modifications from noise in epitranscriptome maps. Nature chemical biology. 2018 Academic Article GET IT
Times cited: 63
Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1. Nature communications. 2018 Academic Article GET IT
Times cited: 202
A Staufen1-mediated decay pathway influences the local transcriptome in axons. Translation (Austin, Tex.). 2017 Academic Article GET IT
Times cited: 46
Reading m⁶A in the Transcriptome: m⁶A-Binding Proteins. Trends in cell biology. 2017 Review GET IT
Times cited: 334
Defining the location of promoter-associated R-loops at near-nucleotide resolution using bisDRIP-seq. eLife. 2017 Academic Article GET IT
Times cited: 67
Epitranscriptomics: Shrinking maps of RNA modifications. Nature. 2017 Comment GET IT
Times cited: 19
RNA-Based Fluorescent Biosensors for Detecting Metabolites in vitro and in Living Cells. Advances in pharmacology (San Diego, Calif.). 2017 Review GET IT
Times cited: 23
A homodimer interface without base pairs in an RNA mimic of red fluorescent protein. Nature chemical biology. 2017 Academic Article GET IT
Times cited: 79
Imaging RNA polymerase III transcription using a photostable RNA-fluorophore complex. Nature chemical biology. 2017 Academic Article GET IT
Times cited: 155
The N⁶-methyladenosine (m⁶A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nature medicine. 2017 Academic Article GET IT
Times cited: 739
Rethinking m⁶A Readers, Writers, and Erasers. Annual review of cell and developmental biology. 2017 Review GET IT
Times cited: 626
The m⁶A pathway facilitates sex determination in Drosophila. Nature communications. 2017 Academic Article GET IT
Times cited: 116
MetaPlotR: a Perl/R pipeline for plotting metagenes of nucleotide modifications and other transcriptomic sites. Bioinformatics (Oxford, England). 2017 Academic Article GET IT
Times cited: 67
Emerging links between m⁶A and misregulated mRNA methylation in cancer. Genome medicine. 2017 Academic Article GET IT
Times cited: 88
Mapping m⁶A at Individual-Nucleotide Resolution Using Crosslinking and Immunoprecipitation (miCLIP). Methods in molecular biology (Clifton, N.J.). 2017 Academic Article GET IT
Times cited: 56
Reversible methylation of m⁶A_m in the 5' cap controls mRNA stability. Nature. 2016 Academic Article GET IT
Times cited: 660
m(6)A RNA methylation promotes XIST-mediated transcriptional repression. Nature. 2016 Academic Article GET IT
Times cited: 997
Tracking translation one mRNA at a time. Nature biotechnology. 2016 Comment GET IT
Small Molecule Recognition and Tools to Study Modulation of r(CGG)(exp) in Fragile X-Associated Tremor Ataxia Syndrome. ACS chemical biology. 2016 Academic Article GET IT
Times cited: 35
Peptide Synthesis on a Next-Generation DNA Sequencing Platform. Chembiochem : a European journal of chemical biology. 2016 Academic Article GET IT
Times cited: 10
Photoacid Behaviour in a Fluorinated Green Fluorescent Protein Chromophore: Ultrafast Formation of Anion and Zwitterion States.^†. Chemical science. 2016 Academic Article GET IT
Times cited: 19
Nucleic Acid-Based Nanodevices in Biological Imaging. Annual review of biochemistry. 2016 Review GET IT
Times cited: 95
RNA modifications: what have we learned and where are we headed?. Nature reviews. Genetics. 2016 Review GET IT
Times cited: 169
Developing Fluorogenic Riboswitches for Imaging Metabolite Concentration Dynamics in Bacterial Cells. Methods in enzymology. 2016 Academic Article GET IT
Times cited: 19
Separating neuronal compartments gives clues as to local effect of ubiquitin conjugates in synaptogenesis. The Journal of cell biology. 2016 Comment GET IT
Times cited: 1
RNA Imaging with Dimeric Broccoli in Live Bacterial and Mammalian Cells. Current protocols in chemical biology. 2016 Academic Article GET IT
Times cited: 33
Fluorescent RNA Aptamers as a Tool to Study RNA-Modifying Enzymes. Cell chemical biology. 2016 Academic Article GET IT
Times cited: 46
Expanding the diversity of DNA base modifications with N⁶-methyldeoxyadenosine. Genome biology. 2016 Academic Article GET IT
Times cited: 10
Preface. Methods in enzymology. 2016 Editorial Article GET IT
5' UTR m(6)A Promotes Cap-Independent Translation. Cell. 2015 Academic Article GET IT
Times cited: 1138
Dynamic m(6)A mRNA methylation directs translational control of heat shock response. Nature. 2015 Academic Article GET IT
Times cited: 825
A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2015 Academic Article GET IT
Times cited: 38
Editorial overview: Molecular imaging: Cellular imaging approaches. Current opinion in chemical biology. 2015 Editorial Article GET IT
Times cited: 1
Metazoan tRNA introns generate stable circular RNAs in vivo. RNA (New York, N.Y.). 2015 Academic Article GET IT
Times cited: 133
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome. Nature methods. 2015 Academic Article GET IT
Times cited: 900
In-gel imaging of RNA processing using broccoli reveals optimal aptamer expression strategies. Chemistry & biology. 2015 Academic Article GET IT
Times cited: 104
Imaging metabolite dynamics in living cells using a Spinach-based riboswitch. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 141
Coupled local translation and degradation regulate growth cone collapse. Nature communications. 2015 Academic Article GET IT
Times cited: 39
Designing optogenetically controlled RNA for regulating biological systems. Annals of the New York Academy of Sciences. 2015 Review GET IT
Times cited: 13
Live-cell imaging of mammalian RNAs with Spinach2. Methods in enzymology. 2015 Academic Article GET IT
Times cited: 22
RNA editing, epitranscriptomics, and processing in cancer progression. Cancer biology & therapy. 2015 Conference Paper GET IT
Times cited: 16
Structure and Mechanism of RNA Mimics of Green Fluorescent Protein. Annual review of biophysics. 2015 Review GET IT
Times cited: 87
Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss. Cell metabolism. 2014 Academic Article GET IT
Times cited: 204
Broccoli: rapid selection of an RNA mimic of green fluorescent protein by fluorescence-based selection and directed evolution. Journal of the American Chemical Society. 2014 Academic Article GET IT
Times cited: 435
An expanding universe of mRNA modifications. Nature structural & molecular biology. 2014 Academic Article GET IT
Times cited: 29
Structural basis for activity of highly efficient RNA mimics of green fluorescent protein. Nature structural & molecular biology. 2014 Academic Article GET IT
Times cited: 252
NAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 29
The dynamic epitranscriptome: N6-methyladenosine and gene expression control. Nature reviews. Molecular cell biology. 2014 Review GET IT
Times cited: 657
Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome. Science (New York, N.Y.). 2014 Academic Article GET IT
Times cited: 218
Plug-and-play fluorophores extend the spectral properties of Spinach. Journal of the American Chemical Society. 2014 Academic Article GET IT
Times cited: 181
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling. Cell. 2014 Academic Article GET IT
Times cited: 124
Profiling lysine ubiquitination by selective enrichment of ubiquitin remnant-containing peptides. Methods in molecular biology (Clifton, N.J.). 2014 Academic Article GET IT
Times cited: 9
Using Spinach-based sensors for fluorescence imaging of intracellular metabolites and proteins in living bacteria. Nature protocols. 2013 Academic Article GET IT
Times cited: 93
The DNA replication program is altered at the FMR1 locus in fragile X embryonic stem cells. Molecular cell. 2013 Academic Article GET IT
Times cited: 79
A superfolding Spinach2 reveals the dynamic nature of trinucleotide repeat-containing RNA. Nature methods. 2013 Academic Article GET IT
Times cited: 256
Axonal transcription factors: novel regulators of growth cone-to-nucleus signaling. Developmental neurobiology. 2013 Review GET IT
Times cited: 30
Global profiling of stimulus-induced polyadenylation in cells using a poly(A) trap. Nature chemical biology. 2013 Academic Article GET IT
Times cited: 47
A mental retardation-linked nonsense mutation in cereblon is rescued by proteasome inhibition. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 35
Imaging bacterial protein expression using genetically encoded RNA sensors. Nature methods. 2013 Academic Article GET IT
Times cited: 115
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nature neuroscience. 2013 Academic Article GET IT
Times cited: 353
New approaches for sensing metabolites and proteins in live cells using RNA. Current opinion in chemical biology. 2013 Review GET IT
Times cited: 38
Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay. Cell. 2013 Academic Article GET IT
Times cited: 140
Comprehensive profiling of protein ubiquitination for drug discovery. Current pharmaceutical design. 2013 Review GET IT
Times cited: 10
Proteomic identification of protein ubiquitination events. Biotechnology & genetic engineering reviews. 2013 Review GET IT
Times cited: 50
The birth of the Epitranscriptome: deciphering the function of RNA modifications. Genome biology. 2012 Academic Article GET IT
Times cited: 318
Intra-axonal translation of RhoA promotes axon growth inhibition by CSPG. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 45
Insights into the roles of local translation from the axonal transcriptome. Open biology. 2012 Review GET IT
Times cited: 43
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Academic Article GET IT
Times cited: 2512
Intra-axonal translation of SMAD1/5/8 mediates retrograde regulation of trigeminal ganglia subtype specification. Neuron. 2012 Academic Article GET IT
Times cited: 67
Fluorescence imaging of cellular metabolites with RNA. Science (New York, N.Y.). 2012 Academic Article GET IT
Times cited: 400
Chemical genetic-mediated spatial regulation of protein expression in neurons reveals an axonal function for wld(s). Chemistry & biology. 2012 Academic Article GET IT
Times cited: 16
Reprogramming axonal behavior by axon-specific viral transduction. Gene therapy. 2012 Academic Article GET IT
Times cited: 27
The new landscape of protein ubiquitination. Nature biotechnology. 2011 Article GET IT
Times cited: 27
Cyclic amino acid linkers stabilizing key loops of brain derived neurotrophic factor. Bioorganic & medicinal chemistry letters. 2011 Academic Article GET IT
Times cited: 11
Chemoenzymatic labeling of protein C-termini for positive selection of C-terminal peptides. ACS chemical biology. 2011 Letter GET IT
Times cited: 40
RNA mimics of green fluorescent protein. Science (New York, N.Y.). 2011 Academic Article GET IT
Times cited: 912
Neurotrophin-mediated dendrite-to-nucleus signaling revealed by microfluidic compartmentalization of dendrites. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 83
Assembling ligands in situ using bioorthogonal boronate ester synthesis. Chemistry & biology. 2010 Academic Article GET IT
Times cited: 31
N-CLAP: global profiling of N-termini by chemoselective labeling of the alpha-amine of proteins. Cold Spring Harbor protocols. 2010 Academic Article GET IT
Times cited: 6
Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling. Nature biotechnology. 2010 Academic Article GET IT
Times cited: 405
Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 80
HDAC6 is a target for protection and regeneration following injury in the nervous system. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 255
Axonal elongation triggered by stimulus-induced local translation of a polarity complex protein. Nature cell biology. 2009 Academic Article GET IT
Times cited: 149
Nitrosothiol reactivity profiling identifies S-nitrosylated proteins with unexpected stability. Chemistry & biology. 2008 Academic Article GET IT
Times cited: 150
Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival. Nature cell biology. 2008 Academic Article GET IT
Times cited: 229
Function and translational regulation of mRNA in developing axons. Seminars in cell & developmental biology. 2007 Review GET IT
Times cited: 62
Pharmacologic manipulation of nitric oxide signaling: targeting NOS dimerization and protein-protein interactions. Current topics in medicinal chemistry. 2007 Review GET IT
Times cited: 48
Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nature neuroscience. 2006 Academic Article GET IT
Times cited: 88
Functional and selective RNA interference in developing axons and growth cones. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Academic Article GET IT
Times cited: 148
Local translation of RhoA regulates growth cone collapse. Nature. 2005 Academic Article GET IT
Times cited: 346
Detection and characterization of protein nitrosothiols. Methods in enzymology. 2005 Academic Article GET IT
Times cited: 29
Ligand discovery using small molecule microarrays. The Journal of pharmacology and experimental therapeutics. 2004 Review GET IT
Times cited: 31
Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue. Chemistry & biology. 2002 Academic Article GET IT
Times cited: 59
Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON. Proceedings of the National Academy of Sciences of the United States of America. 2002 Academic Article GET IT
Times cited: 102
The biotin switch method for the detection of S-nitrosylated proteins. Science's STKE : signal transduction knowledge environment. 2001 Academic Article GET IT
Times cited: 703
Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nature cell biology. 2001 Academic Article GET IT
Times cited: 1230
Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. Neuron. 2000 Academic Article GET IT
Times cited: 275
Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy. The Journal of clinical investigation. 2000 Academic Article GET IT
Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy. The Journal of clinical investigation. 2000 Academic Article GET IT
Times cited: 226
Structure of the PIN/LC8 dimer with a bound peptide. Nature structural biology. 1999 Academic Article GET IT
Times cited: 146
Vessels vivified by Akt acting on NO synthase. Nature cell biology. 1999 Article GET IT
Times cited: 14
Haem oxygenase-1 prevents cell death by regulating cellular iron. Nature cell biology. 1999 Academic Article GET IT
Times cited: 472
Nitric oxide and carbon monoxide: parallel roles as neural messengers. Brain research. Brain research reviews. 1998 Review GET IT
Times cited: 218
CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95. Neuron. 1998 Academic Article GET IT
Times cited: 309
Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide. Proceedings of the National Academy of Sciences of the United States of America. 1997 Academic Article GET IT
Times cited: 217
PIN: an associated protein inhibitor of neuronal nitric oxide synthase. Science (New York, N.Y.). 1996 Academic Article GET IT
Times cited: 427
Nitric oxide: a neural messenger. Annual review of cell and developmental biology. 1995 Review GET IT
Times cited: 308
The iron-responsive element binding protein: a target for synaptic actions of nitric oxide. Proceedings of the National Academy of Sciences of the United States of America. 1994 Academic Article GET IT
Times cited: 69
The interaction between the iron-responsive element binding protein and its cognate RNA is highly dependent upon both RNA sequence and structure. Nucleic acids research. 1993 Academic Article GET IT
Times cited: 90

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Research

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Funding awarded

New mechanisms and technologies for understanding post-transcriptional gene regulation in neurons awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2019 - 2027
Center for Genomic Information Encoded by RNA Nucleotide Modifications awarded by National Human Genome Research Institute Principal Investigator 2021 - 2026
Addgene 766855 awarded by Addgene, Inc. Principal Investigator 2023 - 2024
Mechanisms and functions of N6-methyladenosine (m6A) in cancer awarded by National Cancer Institute Principal Investigator 2019 - 2024
The cap epitranscriptome: Regulation of mRNA fate and function by cap-associated methyl modifications awarded by National Institute of Mental Health Principal Investigator 2019 - 2024
Addgene 704115 awarded by Addgene, Inc. Principal Investigator 2022 - 2023
Addgene 703074 awarded by Addgene, Inc. Principal Investigator 2022 - 2023
Post transcriptional regulation of skin stem cells by M6A RNA methylation. awarded by Tri-Institutional Stem Cell Initiative (Weill Cornell) Principal Investigator 2021 - 2023
Real-time imaging of metabolic deregulation in cancer awarded by Starr Cancer Consortium Principal Investigator 2019 - 2023

Pho-m6A assay: A phosphoselective method to quantify dynamics of m6A in mRNA awarded by National Institute of Environmental Health Sciences Key Personnel 2020 - 2023

Spermatogenic Gene Regulation and Infertility awarded by National Institute of General Medical Sciences Principal Investigator Subaward 2021 - 2026

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Background

education and training

M.D., Ph.D., The Johns Hopkins University School of Medicine 1999
B.S., Massachusetts Institute of Technology 1992

Contact

full name

Samie R Jaffrey

primary email

srj2003@med.cornell.edu

VIVO Weill Cornell Medical College

Samie R Jaffrey Professor of Pharmacology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email