Cellular genomic maps help dissect pathology in human skin disease. Academic Article uri icon

Overview

abstract

  • Genomic signature maps of different cell types can aid in the interpretation of genomic data of specimens collected during disease states. We have defined "lineage-specific" genes, as well as "activation" genes, for cellular components of the skin: keratinocytes, fibroblasts, macrophages, monocytes, T cells, immature, and mature dendritic cells (DCs). Re-analysis of a previously published gene set of psoriasis then provided a model for assessing the usefulness of these maps. We were able to ascribe over 90% of these genes to specific cell types, and there was a surprisingly large contribution from DCs. This shows the utility of such cellular gene maps.

publication date

  • October 11, 2007

Research

keywords

  • Chromosome Mapping
  • Genomics
  • Skin
  • Skin Diseases

Identity

Scopus Document Identifier

  • 39149107433

Digital Object Identifier (DOI)

  • 10.1038/sj.jid.5701067

PubMed ID

  • 17928892

Additional Document Info

volume

  • 128

issue

  • 3