Arousal of cerebral cortex electroencephalogram consequent to high-frequency stimulation of ventral medullary reticular formation. Academic Article uri icon

Overview

abstract

  • We have theorized that large neurons in the ventral and medial reticular formation of the medulla are critical for both autonomic and cortical arousal. To test this theory, we anesthetized rats with urethane, lowered concentric bipolar stimulating electrodes into the medullary reticular formation, and implanted electroencephalogram (EEG) and ECG recording electrodes. We stimulated in the medulla with pulse frequencies ranging from 50 to 300 Hz while recording cortical EEG and ECG. These female rats were ovariectomized, and one subgroup was administered estradiol. Electrical stimulation at either 200 or 300 Hz among the large medullary reticular neurons in nucleus paragigantocellularis (PGi) caused a significant reduction in the portion of the EEG power spectrum represented by delta-waves (0.1-4 Hz) and -waves (4.1-8 Hz). Correspondingly, there were increases in gamma-wave power (22-50 Hz), especially when using 300 Hz. Stimulation at

publication date

  • November 5, 2007

Research

keywords

  • Cerebral Cortex
  • Electroencephalography
  • Medulla Oblongata

Identity

PubMed Central ID

  • PMC2084336

Scopus Document Identifier

  • 36749025731

Digital Object Identifier (DOI)

  • 10.1073/pnas.0708620104

PubMed ID

  • 17984058

Additional Document Info

volume

  • 104

issue

  • 46