Nicotinamide adenine dinucleotide: beyond a redox coenzyme. Review uri icon

Overview

abstract

  • ADP-ribosylation using nicotinamide adenine dinucleotide (NAD+) is an important type of enzymatic reaction that affects many biological processes. A brief introductory review is given here to various ADP-ribosyltransferases, including poly(ADP-ribose) polymerase (PARPs), mono(ADP-ribosyl)-transferases (ARTs), NAD(+)-dependent deacetylases (sirtuins), tRNA 2'-phosphotransferases, and ADP-ribosyl cyclases (CD38 and CD157). Focus is given to the enzymatic reactions, mechanisms, structures, and biological functions.

publication date

  • August 21, 2007

Research

keywords

  • NAD

Identity

Scopus Document Identifier

  • 34547607850

Digital Object Identifier (DOI)

  • 10.1039/b706887e

PubMed ID

  • 18019526

Additional Document Info

volume

  • 5

issue

  • 16