Lin, Hening

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selected publications

N-Myristoyltransferase as a Glycine and Lysine Myristoyltransferase in Cancer, Immunity, and Infections. ACS chemical biology. 2020 Review GET IT
Times cited: 14
TiPARP forms nuclear condensates to degrade HIF-1α and suppress tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 32
NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Nature communications. 2020 Academic Article GET IT
Times cited: 42
A Regulatory Cysteine Residue Mediates Reversible Inactivation of NAD⁺-Dependent Aldehyde Dehydrogenases to Promote Oxidative Stress Response. ACS chemical biology. 2019 Academic Article GET IT
Times cited: 3
The Crystal Structure of Dph2 in Complex with Elongation Factor 2 Reveals the Structural Basis for the First Step of Diphthamide Biosynthesis. Biochemistry. 2019 Academic Article GET IT
Times cited: 3
SIRT2 and Lysine Fatty Acylation Regulate the Activity of RalB and Cell Migration. ACS chemical biology. 2019 Academic Article GET IT
Times cited: 22
A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors. ACS chemical biology. 2019 Academic Article GET IT
Times cited: 16
Activity-Guided Design of HDAC11-Specific Inhibitors. ACS chemical biology. 2019 Academic Article GET IT
Times cited: 28
Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model. Journal of medicinal chemistry. 2019 Academic Article GET IT
Times cited: 33
Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. Developmental cell. 2019 Academic Article GET IT
Times cited: 81
Updates on the epigenetic roles of sirtuins. Current opinion in chemical biology. 2019 Review GET IT
Times cited: 40
HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 94
Fluorogenic Assays for the Defatty-Acylase Activity of Sirtuins. Methods in molecular biology (Clifton, N.J.). 2019 Academic Article GET IT
Times cited: 2
Global Profiling of Sirtuin Deacylase Substrates Using a Chemical Proteomic Strategy and Validation by Fluorescent Labeling. Methods in molecular biology (Clifton, N.J.). 2019 Academic Article GET IT
Times cited: 2
SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation. eLife. 2017 Academic Article GET IT
Times cited: 59
Substrate-Dependent Cleavage Site Selection by Unconventional Radical S-Adenosylmethionine Enzymes in Diphthamide Biosynthesis. Journal of the American Chemical Society. 2017 Academic Article GET IT
Times cited: 14
Deacylation Mechanism by SIRT2 Revealed in the 1'-SH-2'-O-Myristoyl Intermediate Structure. Cell chemical biology. 2017 Academic Article GET IT
Times cited: 32
S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration. The Journal of biological chemistry. 2017 Academic Article GET IT
Times cited: 27
Cbr1 is a Dph3 reductase required for the tRNA wobble uridine modification. Nature chemical biology. 2016 Academic Article GET IT
Times cited: 11
SIRT2 Reverses 4-Oxononanoyl Lysine Modification on Histones. Journal of the American Chemical Society. 2016 Academic Article GET IT
Times cited: 56
HDAC8 Catalyzes the Hydrolysis of Long Chain Fatty Acyl Lysine. ACS chemical biology. 2016 Academic Article GET IT
Times cited: 69
Organometallic Complex Formed by an Unconventional Radical S-Adenosylmethionine Enzyme. Journal of the American Chemical Society. 2016 Academic Article GET IT
Times cited: 16
Identifying the functional contribution of the defatty-acylase activity of SIRT6. Nature chemical biology. 2016 Academic Article GET IT
Times cited: 69
Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science (New York, N.Y.). 2016 Academic Article GET IT
Times cited: 240
A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity. Cancer cell. 2016 Academic Article GET IT
Times cited: 26
Lessons learned from a SIRT2-selective inhibitor. Oncotarget. 2016 Editorial Article GET IT
Times cited: 2
The Substrate Specificity of Sirtuins. Annual review of biochemistry. 2016 Review GET IT
Times cited: 165
Lysine fatty acylation promotes lysosomal targeting of TNF-α. Scientific reports. 2016 Academic Article GET IT
Times cited: 27
A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity. Cancer cell. 2016 Article GET IT
Times cited: 26
Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 204
A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity. Cancer cell. 2016 Academic Article GET IT
Times cited: 148
SIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context. ACS chemical biology. 2016 Academic Article GET IT
Times cited: 44
An improved fluorogenic assay for SIRT1, SIRT2, and SIRT3. Organic & biomolecular chemistry. 2016 Academic Article GET IT
Times cited: 21
Molecular dissection of a putative iron reductase from Desulfotomaculum reducens MI-1. Biochemical and biophysical research communications. 2015 Academic Article GET IT
Times cited: 1
High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet. Molecular & cellular proteomics : MCP. 2015 Academic Article GET IT
Times cited: 73
Efficient demyristoylase activity of SIRT2 revealed by kinetic and structural studies. Scientific reports. 2015 Academic Article GET IT
Times cited: 124
Sirtuins in epigenetic regulation. Chemical reviews. 2015 Review GET IT
Times cited: 163
Identification of proteins capable of metal reduction from the proteome of the Gram-positive bacterium Desulfotomaculum reducens MI-1 using an NADH-based activity assay. Environmental microbiology. 2015 Academic Article GET IT
Times cited: 11
Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors. Organic & biomolecular chemistry. 2014 Academic Article GET IT
Times cited: 61
Sirtuin inhibitors as anticancer agents. Future medicinal chemistry. 2014 Review GET IT
Times cited: 126
Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis. Journal of the American Chemical Society. 2014 Academic Article GET IT
Times cited: 20
Revealing CD38 cellular localization using a cell permeable, mechanism-based fluorescent small-molecule probe. Journal of the American Chemical Society. 2014 Academic Article GET IT
Times cited: 40
Dph3 is an electron donor for Dph1-Dph2 in the first step of eukaryotic diphthamide biosynthesis. Journal of the American Chemical Society. 2014 Academic Article GET IT
Times cited: 52
Identification of lysine succinylation substrates and the succinylation regulatory enzyme CobB in Escherichia coli. Molecular & cellular proteomics : MCP. 2013 Academic Article GET IT
Times cited: 183
Metabolic characterization of a Sirt5 deficient mouse model. Scientific reports. 2013 Academic Article GET IT
Times cited: 102
A fluorogenic assay for screening Sirt6 modulators. Organic & biomolecular chemistry. 2013 Academic Article GET IT
Times cited: 41
The biosynthesis and biological function of diphthamide. Critical reviews in biochemistry and molecular biology. 2013 Review GET IT
Times cited: 56
SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature. 2013 Academic Article GET IT
Times cited: 523
Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature. 2013 Academic Article GET IT
Times cited: 2262
Detecting sirtuin-catalyzed deacylation reactions using ³²P-labeled NAD and thin-layer chromatography. Methods in molecular biology (Clifton, N.J.). 2013 Academic Article GET IT
Times cited: 3
Chemogenomic approach identified yeast YLR143W as diphthamide synthetase. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 22
Identification of ADP-ribosylation sites of CD38 mutants by precursor ion scanning mass spectrometry. Analytical biochemistry. 2012 Academic Article GET IT
Times cited: 7
The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5). The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 66
Protein lysine acylation and cysteine succination by intermediates of energy metabolism. ACS chemical biology. 2012 Review GET IT
Times cited: 178
Thiosuccinyl peptides as Sirt5-specific inhibitors. Journal of the American Chemical Society. 2012 Academic Article GET IT
Times cited: 67
YBR246W is required for the third step of diphthamide biosynthesis. Journal of the American Chemical Society. 2011 Academic Article GET IT
Times cited: 28
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (New York, N.Y.). 2011 Academic Article GET IT
Times cited: 736
Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine. ACS chemical biology. 2011 Academic Article GET IT
Times cited: 55
S-Adenosylmethionine-dependent alkylation reactions: when are radical reactions used?. Bioorganic chemistry. 2011 Review GET IT
Times cited: 34
ATRA-induced HL-60 myeloid leukemia cell differentiation depends on the CD38 cytosolic tail needed for membrane localization, but CD38 enzymatic activity is unnecessary. Experimental cell research. 2010 Academic Article GET IT
Times cited: 19
Protein posttranslational modifications: chemistry, biology, and applications. Molecular bioSystems. 2010 Editorial Article GET IT
Times cited: 11
Reconstitution of diphthine synthase activity in vitro. Biochemistry. 2010 Academic Article GET IT
Times cited: 17
Mechanistic understanding of Pyrococcus horikoshii Dph2, a [4Fe-4S] enzyme required for diphthamide biosynthesis. Molecular bioSystems. 2010 Academic Article GET IT
Times cited: 32
Clickable NAD analogues for labeling substrate proteins of poly(ADP-ribose) polymerases. Journal of the American Chemical Society. 2010 Academic Article GET IT
Times cited: 95
Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme. Nature. 2010 Academic Article GET IT
Times cited: 158
Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 50
Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD. Biochemistry. 2009 Academic Article GET IT
Times cited: 134
Mechanism-based small molecule probes for labeling CD38 on live cells. Journal of the American Chemical Society. 2009 Academic Article GET IT
Times cited: 25
High-throughput selection for cellulase catalysts using chemical complementation. Journal of the American Chemical Society. 2008 Academic Article GET IT
Times cited: 36
Covalent and noncovalent intermediates of an NAD utilizing enzyme, human CD38. Chemistry & biology. 2008 Academic Article GET IT
Times cited: 38
Nicotinamide adenine dinucleotide: beyond a redox coenzyme. Organic & biomolecular chemistry. 2007 Review GET IT
Times cited: 65
The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 237
Structural characterization of enterobactin hydrolase IroE. Biochemistry. 2006 Academic Article GET IT
Times cited: 32
Bromoenterobactins as potent inhibitors of a pathogen-associated, siderophore-modifying C-glycosyltransferase. Journal of the American Chemical Society. 2006 Academic Article GET IT
Times cited: 7
Optimized design and synthesis of chemical dimerizer substrates for detection of glycosynthase activity via chemical complementation. Bioorganic & medicinal chemistry. 2006 Academic Article GET IT
Times cited: 9
How pathogenic bacteria evade mammalian sabotage in the battle for iron. Nature chemical biology. 2006 Review GET IT
Times cited: 242
Investigation of the mechanism of resistance to third-generation cephalosporins by class C beta-lactamases by using chemical complementation. Chembiochem : a European journal of chemical biology. 2005 Academic Article GET IT
Times cited: 13
In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes. Journal of the American Chemical Society. 2005 Academic Article GET IT
Times cited: 140
In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 139
Macrolactamization of glycosylated peptide thioesters by the thioesterase domain of tyrocidine synthetase. Chemistry & biology. 2004 Academic Article GET IT
Times cited: 41
Directed evolution of a glycosynthase via chemical complementation. Journal of the American Chemical Society. 2004 Academic Article GET IT
Times cited: 93
A chemoenzymatic approach to glycopeptide antibiotics. Journal of the American Chemical Society. 2004 Academic Article GET IT
Times cited: 155
Enhanced macrocyclizing activity of the thioesterase from tyrocidine synthetase in presence of nonionic detergent. Chemistry & biology. 2004 Academic Article GET IT
Times cited: 26
Correlation between catalytic efficiency and the transcription read-out in chemical complementation: a general assay for enzyme catalysis. Biochemistry. 2004 Academic Article GET IT
Times cited: 15
Programming peptidomimetic syntheses by translating genetic codes designed de novo. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 157
Chemical complementation: a reaction-independent genetic assay for enzyme catalysis. Proceedings of the National Academy of Sciences of the United States of America. 2002 Academic Article GET IT
Times cited: 86
Screening and selection methods for large-scale analysis of protein function. Angewandte Chemie (International ed. in English). 2002 Review GET IT
Times cited: 122
Receptor-dependence of the transcription read-out in a small-molecule three-hybrid system. Chembiochem : a European journal of chemical biology. 2002 Academic Article GET IT
Times cited: 30
In Vivo Protein-Protein Interaction Assays: Beyond Proteins. Angewandte Chemie (International ed. in English). 2001 Academic Article GET IT

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Background

education and training

Ph.D., Columbia University 2003
B.S., Tsinghua University (China) 1998

Contact

full name

Hening Lin

VIVO Weill Cornell Medical College

Hening Lin Tri-Institutional Professor

Publications

selected publications

Background

education and training

Contact

full name