Plasma profiles of adrenocorticotropic hormone, cortisol, growth hormone and prolactin in patients with untreated Parkinson's disease. Academic Article uri icon

Overview

abstract

  • Plasma profiles of prolactin, growth hormone, adrenocorticotropic hormone (ACTH) and cortisol were evaluated in a group of untreated patients with idiopathic Parkinson's disease and a group of healthy age-matched controls. Plasma integrated concentrations of all hormones except prolactin were significantly lower in the patients as compared with the controls; however, prolactin nocturnal peak concentration was significantly elevated in the patients; nocturnal growth hormone levels were significantly reduced in the Parkinson group; ACTH and cortisol plasma concentrations were also consistently lower during most of the day in the patients with Parkinson's disease. These data confirm the presence of a hypothalamic disturbance in patients with idiopathic Parkinson's disease, which can affect pituitary function.

publication date

  • February 1, 1991

Research

keywords

  • Adrenocorticotropic Hormone
  • Growth Hormone
  • Hydrocortisone
  • Parkinson Disease
  • Prolactin

Identity

Scopus Document Identifier

  • 0025972572

Digital Object Identifier (DOI)

  • 10.1007/BF00319704

PubMed ID

  • 1851513

Additional Document Info

volume

  • 238

issue

  • 1