The RSK family of kinases: emerging roles in cellular signalling. Review uri icon

Overview

abstract

  • The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved Ser/Thr kinases that regulate diverse cellular processes, such as cell growth, cell motility, cell survival and cell proliferation. RSKs are downstream effectors of the Ras-extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signalling cascade. Significant advances in the field of RSK and ERK/MAPK signalling have occurred in the past few years, including biological insights and the discovery of novel substrates and new RSK regulatory mechanisms. Collectively, these data expand the current models of RSK signalling and highlight potential directions of research in RSK-mediated survival, growth, proliferation and migration.

publication date

  • October 1, 2008

Research

keywords

  • MAP Kinase Signaling System
  • Ribosomal Protein S6 Kinases, 90-kDa

Identity

Scopus Document Identifier

  • 52449095361

Digital Object Identifier (DOI)

  • 10.1038/nrm2509

PubMed ID

  • 18813292

Additional Document Info

volume

  • 9

issue

  • 10