Crystallographic cryoenzymology and the legacy of Tony Fink. Review uri icon

Overview

abstract

  • During the past thirty years significant contributions to our understanding of the structural origins of the catalytic power of enzymes have come from solution and crystallographic studies of enzyme-substrate and enzyme-intermediate complexes trapped at subzero temperatures, a field that was pioneered in large part by Anthony L. Fink and Pierre Douzou. Here I review, from a personal perspective, the history of crystallographic cryoenzymology, with an emphasis on the contributions of Tony Fink. The story has a moral: if you choose your collaborators based not only on their scientific prowess but also on their human qualities, the resulting friendships will enrich your life.

publication date

  • October 1, 2009

Research

keywords

  • Biochemistry
  • Crystallography, X-Ray

Identity

Scopus Document Identifier

  • 70349509884

Digital Object Identifier (DOI)

  • 10.2174/138920309789351985

PubMed ID

  • 19538155

Additional Document Info

volume

  • 10

issue

  • 5