Petsko, Gregory

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25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner. Journal of neuroinflammation. 2020 Academic Article GET IT
Times cited: 35
High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3. Scientific reports. 2018 Academic Article GET IT
Times cited: 21
Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membrane. Journal of cell science. 2018 Academic Article GET IT
Times cited: 16
Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations. 2018 GET IT
Times cited: 173
Crystal Structures of Cystathionine β-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time. Biochemistry. 2018 Academic Article GET IT
Times cited: 21
AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease. Human gene therapy. Clinical development. 2018 Academic Article GET IT
Times cited: 70
Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein. Stem cell reports. 2018 Academic Article GET IT
Times cited: 59
Crystal Structure of Green Fluorescent Protein Clover and Design of Clover-Based Redox Sensors. Structure (London, England : 1993). 2018 Academic Article GET IT
Times cited: 13
Parkinson's Disease and Melanoma: Co-Occurrence and Mechanisms. Journal of Parkinson's disease. 2018 Review GET IT
Times cited: 58
Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer's Disease. Trends in neurosciences. 2017 Review GET IT
Times cited: 79
Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c). Biochemistry. 2017 Academic Article GET IT
Times cited: 8
PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 21
Dual chemistry catalyzed by human acireductone dioxygenase. Protein engineering, design & selection : PEDS. 2017 Academic Article GET IT
Times cited: 11
Structure and mechanism of benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633, a member of the Class 3 aldehyde dehydrogenase superfamily. Protein engineering, design & selection : PEDS. 2017 Academic Article GET IT
Times cited: 5
A functional role for intrinsic disorder in the tau-tubulin complex. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 48
Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 16
Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 168
Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 68
Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2016 Academic Article GET IT
Times cited: 1
Metal-Dependent Function of a Mammalian Acireductone Dioxygenase. Biochemistry. 2016 Academic Article GET IT
Times cited: 33
Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 25
Peptide dimer structure in an Aβ(1-42) fibril visualized with cryo-EM. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 172
Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 125
Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 82
Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations. The Lancet. Neurology. 2015 Review GET IT
Times cited: 341
A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 37
Retromer in Alzheimer disease, Parkinson disease and other neurological disorders. Nature reviews. Neuroscience. 2015 Review GET IT
Times cited: 174
The use of pharmacological retromer chaperones in Alzheimer's disease and other endosomal-related disorders. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2015 Review GET IT
Times cited: 26
Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis. Gene therapy. 2014 Academic Article GET IT
Times cited: 51
Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Academic Article GET IT
Times cited: 73
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2014 Academic Article GET IT
Times cited: 418
Editorial overview--New frontiers of biophysical methods: tools for structural biology and beyond. Current opinion in structural biology. 2014 Editorial Article GET IT
Crystal cryocooling distorts conformational heterogeneity in a model Michaelis complex of DHFR. Structure (London, England : 1993). 2014 Academic Article GET IT
Times cited: 88
Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2. PLoS pathogens. 2014 Academic Article GET IT
Times cited: 31
Pharmacological chaperones stabilize retromer to limit APP processing. Nature chemical biology. 2014 Academic Article GET IT
Times cited: 160
Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation. Proteomics. 2014 Academic Article GET IT
Times cited: 16
Structure of a eukaryotic thiaminase I. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 10
Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 51
Open questions: Zombie projects, translational research, and the real secret of the inside of the cell. BMC biology. 2013 Academic Article GET IT
Times cited: 2
Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage. Biochemistry. 2013 Academic Article GET IT
Times cited: 30
Structural consequences of cysteinylation of Cu/Zn-superoxide dismutase. Biochemistry. 2013 Academic Article GET IT
Times cited: 24
Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. The Journal of clinical investigation. 2013 Academic Article GET IT
Times cited: 43
Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 33
A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-γ-lactonase from Bacillus thuringiensis. Biochemistry. 2013 Academic Article GET IT
Times cited: 27
Hypothesis-driven genomics pays off. Genome biology. 2012 Academic Article GET IT
Times cited: 2
Behind the movement. Cell. 2012 Academic Article GET IT
Times cited: 1
Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain. Molecular psychiatry. 2012 Academic Article GET IT
Times cited: 61
Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Molecular psychiatry. 2012 Academic Article GET IT
Times cited: 91
Out of Africa. Genome biology. 2012 Academic Article GET IT
Times cited: 1
Mending walls. BMC biology. 2012 Academic Article GET IT
Times cited: 1
The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK). Bioorganic & medicinal chemistry letters. 2012 Academic Article GET IT
Times cited: 28
A case of the flu. Genome biology. 2012 Academic Article GET IT
The dog particle. Genome biology. 2012 Academic Article GET IT
Apocalypse now?. Genome biology. 2012 Academic Article GET IT
Economies of scale. Genome biology. 2012 Academic Article GET IT
Goodbye, Columbus. Genome biology. 2012 Academic Article GET IT
Times cited: 8
Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast. Journal of Alzheimer's disease : JAD. 2012 Academic Article GET IT
Times cited: 62
Mass spectrometry tools for analysis of intermolecular interactions. Methods in molecular biology (Clifton, N.J.). 2012 Academic Article GET IT
Times cited: 3
The columnist manifesto. Genome biology. 2011 Academic Article GET IT
Analyzing molecular interactions. Current protocols in bioinformatics. 2011 Academic Article GET IT
Times cited: 6
Dominoes. Genome biology. 2011 Academic Article GET IT
Times cited: 1
Bailing out. Genome biology. 2011 Academic Article GET IT
A soluble α-synuclein construct forms a dynamic tetramer. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 371
Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis. Cold Spring Harbor perspectives in biology. 2011 Review GET IT
Times cited: 46
The one new journal we might actually need. Genome biology. 2011 Academic Article GET IT
Times cited: 5
Nothing to do and all day to do it in. Genome biology. 2011 Academic Article GET IT
Herding cats. Science translational medicine. 2011 Editorial Article GET IT
Times cited: 6
Food of the dogs. Genome biology. 2011 Academic Article GET IT
Risky business. Genome biology. 2011 Academic Article GET IT
Times cited: 1
In praise of model organisms. Genome biology. 2011 Editorial Article GET IT
Times cited: 4
Evidence of the participation of remote residues in the catalytic activity of Co-type nitrile hydratase from Pseudomonas putida. Biochemistry. 2011 Academic Article GET IT
Times cited: 42
The blue marble. Genome biology. 2011 Academic Article GET IT
Times cited: 13
Time-of-flight neutron diffraction study of bovine γ-chymotrypsin at the Protein Crystallography Station. Acta crystallographica. Section F, Structural biology and crystallization communications. 2011 Academic Article GET IT
Times cited: 1
A yeast model of FUS/TLS-dependent cytotoxicity. PLoS biology. 2011 Academic Article GET IT
Times cited: 152
The walking dead. Genome biology. 2011 Academic Article GET IT
There is a sanity clause. Genome biology. 2011 Letter GET IT
Preserving some sanity. Genome biology. 2011 Academic Article GET IT
Save university arts from the bean counters. Nature. 2010 Academic Article GET IT
The long and the short of it. Genome biology. 2010 Academic Article GET IT
Every dog has his day in court. Genome biology. 2010 Academic Article GET IT
Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 60
A Faustian bargain. Genome biology. 2010 Academic Article GET IT
Times cited: 6
Shadows on the wall. Genome biology. 2010 Academic Article GET IT
Times cited: 2
Polyamine pathway contributes to the pathogenesis of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 100
The past is a foreign country. Genome biology. 2010 Academic Article GET IT
Hand-made biology. Genome biology. 2010 Academic Article GET IT
Times cited: 1
When failure should be the option. BMC biology. 2010 Academic Article GET IT
Times cited: 32
And they said it wouldn't last.. Genome biology. 2010 Academic Article GET IT
Times cited: 1
The devil's in the details. Genome biology. 2010 Academic Article GET IT
Times cited: 1
No stone unturned. Genome biology. 2010 Academic Article GET IT
Lost in translation. Genome biology. 2010 Academic Article GET IT
Times cited: 2
Rising in the East. Genome biology. 2010 Comment GET IT
Times cited: 1
Active-site engineering of benzaldehyde lyase shows that a point mutation can confer both new reactivity and susceptibility to mechanism-based inhibition. Journal of the American Chemical Society. 2010 Academic Article GET IT
Times cited: 20
When the pie is too small. Genome biology. 2010 Academic Article GET IT
A harsh climate. Genome biology. 2009 Academic Article GET IT
Big science, little science. EMBO reports. 2009 Academic Article GET IT
Times cited: 10
Advice and dissent. Genome biology. 2009 Letter GET IT
The dog days of autumn. Genome biology. 2009 Academic Article GET IT
What are pharmacological chaperones and why are they interesting?. Journal of biology. 2009 Academic Article GET IT
Times cited: 87
Crystallographic cryoenzymology and the legacy of Tony Fink. Current protein & peptide science. 2009 Review GET IT
Times cited: 3
An issue to remember. Genome biology. 2009 Letter GET IT
Wimps? What wimps?. Genome biology. 2009 Academic Article GET IT
Hydrogen bond coupling in the ketosteroid isomerase active site. Biochemistry. 2009 Academic Article GET IT
Times cited: 24
What my genome told me--and what it didn't. Genome biology. 2009 Academic Article GET IT
Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase. Journal of computer-aided molecular design. 2009 Academic Article GET IT
Times cited: 77
Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability. Biochemistry. 2009 Academic Article GET IT
Times cited: 123
Render unto Darwin. Genome biology. 2009 Academic Article GET IT
Guilt by association. Genome biology. 2009 Academic Article GET IT
Times cited: 11
Snapshot of a reaction intermediate: analysis of benzoylformate decarboxylase in complex with a benzoylphosphonate inhibitor. Biochemistry. 2009 Academic Article GET IT
Times cited: 29
The greatest book you never read. EMBO reports. 2009 Academic Article GET IT
Times cited: 1
Too big to succeed?. Genome biology. 2009 Editorial Article GET IT
A preliminary neutron diffraction study of gamma-chymotrypsin. Acta crystallographica. Section F, Structural biology and crystallization communications. 2009 Academic Article GET IT
Times cited: 4
Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylase. Biochemistry. 2009 Academic Article GET IT
Times cited: 19
Life is a Ponzi scheme. Genome biology. 2009 Academic Article GET IT
Times cited: 2
The wisdom, and madness, of crowds. Genome biology. 2008 Academic Article GET IT
Times cited: 3
Meta-morphosis. Genome biology. 2008 Academic Article GET IT
When bubbles burst. Genome biology. 2008 Academic Article GET IT
Testing geometrical discrimination within an enzyme active site: constrained hydrogen bonding in the ketosteroid isomerase oxyanion hole. Journal of the American Chemical Society. 2008 Academic Article GET IT
Times cited: 85
Biodefense versus bioterrorism. Genome biology. 2008 Academic Article GET IT
Times cited: 2
Having an impact (factor). Genome biology. 2008 Academic Article GET IT
Times cited: 14
Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 1. Product-bound structures. Biochemistry. 2008 Academic Article GET IT
Times cited: 86
Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 2. Substrate modeling and active site mutations. Biochemistry. 2008 Academic Article GET IT
Times cited: 80
Zinc coordination geometry and ligand binding affinity: the structural and kinetic analysis of the second-shell serine 228 residue and the methionine 180 residue of the aminopeptidase from Vibrio proteolyticus. Biochemistry. 2008 Academic Article GET IT
Times cited: 33
It is alive. Genome biology. 2008 Academic Article GET IT
Probing the active center of benzaldehyde lyase with substitutions and the pseudosubstrate analogue benzoylphosphonic acid methyl ester. Biochemistry. 2008 Academic Article GET IT
Times cited: 31
Biochemistry. How enzymes work. Science (New York, N.Y.). 2008 Academic Article GET IT
Times cited: 179
The new Manichaeans. Genome biology. 2008 Academic Article GET IT
Not debatable. Genome biology. 2008 Academic Article GET IT
The right to be wrong. Genome biology. 2008 Academic Article GET IT
The story they missed. Genome biology. 2008 Academic Article GET IT
A seat at the table. Genome biology. 2008 Academic Article GET IT
Times cited: 17
Intrinsic motions along an enzymatic reaction trajectory. Nature. 2007 Academic Article GET IT
Times cited: 719
Structure and specificity of a quorum-quenching lactonase (AiiB) from Agrobacterium tumefaciens. Biochemistry. 2007 Academic Article GET IT
Times cited: 82
Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms". Biochemistry. 2007 Academic Article GET IT
Times cited: 13
X-ray crystallographic characterization of the Co(II)-substituted Tris-bound form of the aminopeptidase from Aeromonas proteolytica. Journal of inorganic biochemistry. 2007 Academic Article GET IT
Times cited: 12
A day in the life of a genome biologist in the not-too-distant future. Genome biology. 2007 Academic Article GET IT
An idea whose time has gone. Genome biology. 2007 Academic Article GET IT
Times cited: 19
And the second shall be first. Genome biology. 2007 Academic Article GET IT
Times cited: 13
It can't happen here--can it?. Genome biology. 2007 Academic Article GET IT
Jumping the shark. Genome biology. 2007 Academic Article GET IT
Medicine man. Genome biology. 2007 Editorial Article GET IT
My worries are no longer behind me. Genome biology. 2007 Academic Article GET IT
Strange days. Genome biology. 2007 Academic Article GET IT
They fought the law and the law won. Genome biology. 2007 Academic Article GET IT
What if Watson had said "Apes evolved from man"?. Genome biology. 2007 Academic Article GET IT
Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease. Nature chemical biology. 2006 Academic Article GET IT
Times cited: 208
Direct crystallographic observation of an acyl-enzyme intermediate in the elastase-catalyzed hydrolysis of a peptidyl ester substrate: Exploiting the "glass transition" in protein dynamics. Bioorganic chemistry. 2006 Academic Article GET IT
Times cited: 13
Transformation. Genome biology. 2006 Academic Article GET IT
Times cited: 1
An introduction to modeling structure from sequence. Current protocols in bioinformatics. 2006 Review GET IT
Times cited: 5
The next epidemic. Genome biology. 2006 Academic Article GET IT
Times cited: 4
The high-resolution structures of the neutral and the low pH crystals of aminopeptidase from Aeromonas proteolytica. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 2006 Academic Article GET IT
Times cited: 30
The system is broken. Genome biology. 2006 Academic Article GET IT
Times cited: 3
Testing electrostatic complementarity in enzyme catalysis: hydrogen bonding in the ketosteroid isomerase oxyanion hole. PLoS biology. 2006 Academic Article GET IT
Times cited: 116
Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 152
Sweden has the right idea. Genome biology. 2006 Academic Article GET IT
The highs and lows of scientific conferences. Nature reviews. Molecular cell biology. 2006 Review GET IT
Times cited: 6
Multiple solvent crystal structures: probing binding sites, plasticity and hydration. Journal of molecular biology. 2006 Academic Article GET IT
Times cited: 131
Foxes and hounds. Genome biology. 2006 Academic Article GET IT
A model worth considering?. Genome biology. 2006 Academic Article GET IT
Times cited: 1
Do the math. Genome biology. 2006 Academic Article GET IT
Times cited: 1
Facts and figures. Genome biology. 2006 Academic Article GET IT
Instructions for repair. Genome biology. 2006 Academic Article GET IT
Times cited: 1
Senior moments. Genome biology. 2006 Academic Article GET IT
The ninth wave. Genome biology. 2006 Academic Article GET IT
The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein. Journal of molecular biology. 2005 Academic Article GET IT
Times cited: 312
H5N1. Genome biology. 2005 Academic Article GET IT
Times cited: 1
Half right. Genome biology. 2005 Academic Article GET IT
Kinetic, spectroscopic, and X-ray crystallographic characterization of the functional E151H aminopeptidase from Aeromonas proteolytica. Biochemistry. 2005 Academic Article GET IT
Times cited: 12
The atomic resolution crystal structure of the YajL (ThiJ) protein from Escherichia coli: a close prokaryotic homologue of the Parkinsonism-associated protein DJ-1. Journal of molecular biology. 2005 Academic Article GET IT
Times cited: 57
Trinity. Genome biology. 2005 Academic Article GET IT
Three-dimensional structure of the quorum-quenching N-acyl homoserine lactone hydrolase from Bacillus thuringiensis. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 105
Superman's eyes. Biochimica et biophysica acta. 2005 Editorial Article GET IT
Times cited: 1
The life aquatic. Genome biology. 2005 Academic Article GET IT
Eighty years ago. Genome biology. 2005 Academic Article GET IT
How may you help me?. Genome biology. 2005 Academic Article GET IT
A matter of life and death. Genome biology. 2005 Academic Article GET IT
Times cited: 1
Diversity in hapten recognition: structural study of an anti-cocaine antibody M82G2. Journal of molecular biology. 2005 Academic Article GET IT
Times cited: 32
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 316
Who owns the data?. Genome biology. 2005 Academic Article GET IT
Feet in mouth disease. Genome biology. 2005 Editorial Article GET IT
Times cited: 1
Tsunami. Genome biology. 2005 Academic Article GET IT
Color blind. Genome biology. 2004 Academic Article GET IT
Times cited: 4
The emperor's new shibboleth. Genome biology. 2004 Academic Article GET IT
Times cited: 1
Twilight of a hero. Genome biology. 2004 Academic Article GET IT
Fame is a bubble, but not for some. Genome biology. 2004 Article GET IT
Crystal structure of 3-carboxy-cis,cis-muconate lactonizing enzyme from Pseudomonas putida, a fumarase class II type cycloisomerase: enzyme evolution in parallel pathways. Biochemistry. 2004 Academic Article GET IT
Times cited: 29
Spectroscopic and X-ray crystallographic characterization of bestatin bound to the aminopeptidase from Aeromonas (Vibrio) proteolytica. Biochemistry. 2004 Academic Article GET IT
Times cited: 31
A drop in the bucket. Genome biology. 2004 Academic Article GET IT
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 929
"Sleeping beauty": quiescence in Saccharomyces cerevisiae. Microbiology and molecular biology reviews : MMBR. 2004 Review GET IT
Times cited: 461
Xylose isomerase in substrate and inhibitor michaelis states: atomic resolution studies of a metal-mediated hydride shift. Biochemistry. 2004 Academic Article GET IT
Times cited: 95
Pharmacogenomics arrives. Genome biology. 2004 Review GET IT
Times cited: 3
The ascent of man?. Genome biology. 2004 Academic Article GET IT
Doctor Dunsel. Genome biology. 2004 Academic Article GET IT
Anchoring a cationic ligand: the structure of the Fab fragment of the anti-morphine antibody 9B1 and its complex with morphine. Journal of molecular biology. 2004 Academic Article GET IT
Times cited: 28
Crystal structure at 1.8 A resolution of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis. Biochemistry. 2004 Academic Article GET IT
Times cited: 24
Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases. Biochemistry. 2004 Academic Article GET IT
Times cited: 47
Good chemistry. Genome biology. 2004 Academic Article GET IT
Bad chemistry. Genome biology. 2004 Academic Article GET IT
The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: a member of the DJ-1/ThiJ/PfpI superfamily. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 93
Live and let diet. Genome biology. 2003 Academic Article GET IT
Times cited: 1
For the good of the state. Genome biology. 2003 Academic Article GET IT
Malonate: a versatile cryoprotectant and stabilizing solution for salt-grown macromolecular crystals. Acta crystallographica. Section D, Biological crystallography. 2003 Academic Article GET IT
Times cited: 48
Sleeping dogs. Genome biology. 2003 Academic Article GET IT
Q & A. Current biology : CB. 2003 Article GET IT
Times cited: 1
The usual suspects. Genome biology. 2003 Academic Article GET IT
The 'glass transition' in protein dynamics: what it is, why it occurs, and how to exploit it. Biophysical chemistry. 2003 Review GET IT
Times cited: 204
The road worrier. Genome biology. 2003 Academic Article GET IT
Galileo's stepchildren. Genome biology. 2003 Academic Article GET IT
The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 259
A new recruit for the army of the men of death. Genome biology. 2003 Academic Article GET IT
2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor. Biochemistry. 2003 Academic Article GET IT
Times cited: 90
Ira. Genome biology. 2003 Academic Article GET IT
Analyzing molecular interactions. Current protocols in bioinformatics. 2003 Review GET IT
Times cited: 1
War and peace. Genome biology. 2003 Academic Article GET IT
Galactose mutarotase: pH dependence of enzymatic mutarotation. Biochemistry. 2003 Academic Article GET IT
Times cited: 17
Judgement call. Genome biology. 2003 Academic Article GET IT
Still no flying cars. Genome biology. 2003 Review GET IT
The immunosuppressive agent mizoribine monophosphate forms a transition state analogue complex with inosine monophosphate dehydrogenase. Biochemistry. 2003 Academic Article GET IT
Times cited: 58
Funky, not junky. Genome biology. 2003 Academic Article GET IT
Times cited: 1
Everything I need to know about genomics, I learned from Yogi Berra. Genome biology. 2002 Academic Article GET IT
Crystal structure of a ternary complex of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: NAD+ orients the active site loop for catalysis. Biochemistry. 2002 Academic Article GET IT
Times cited: 58
The guards themselves. Genome biology. 2002 Comment GET IT
Defining the mandate of proteomics in the post-genomics era: workshop report. Molecular & cellular proteomics : MCP. 2002 Conference Paper GET IT
Times cited: 70
An Asilomar moment. Genome biology. 2002 Academic Article GET IT
Times cited: 5
Misfolded proteins are competent to mediate a subset of the responses to heat shock in Saccharomyces cerevisiae. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 129
Fish tale. Genome biology. 2002 Academic Article GET IT
The 1.20 A resolution crystal structure of the aminopeptidase from Aeromonas proteolytica complexed with tris: a tale of buffer inhibition. Structure (London, England : 1993). 2002 Academic Article GET IT
Times cited: 51
No place like Ome. Genome biology. 2002 Academic Article GET IT
Times cited: 6
Our own petards. Genome biology. 2002 Academic Article GET IT
Grain of truth. Genome biology. 2002 Academic Article GET IT
Times cited: 5
What's in a name?. Genome biology. 2002 Academic Article GET IT
Times cited: 11
Why protein R-factors are so large: a self-consistent analysis. Proteins. 2002 Academic Article GET IT
Times cited: 31
Structural mechanism of enoyl-CoA hydratase: three atoms from a single water are added in either an E1cb stepwise or concerted fashion. Biochemistry. 2002 Academic Article GET IT
Times cited: 116
The father of us all. Genome biology. 2002 Academic Article GET IT
Times cited: 1
Purification, crystallization and molecular symmetry of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis. Acta crystallographica. Section D, Biological crystallography. 2002 Academic Article GET IT
Times cited: 1
A christmas carol. Genome biology. 2001 Academic Article GET IT
Times cited: 2
Active site analysis of the potential antimicrobial target aspartate semialdehyde dehydrogenase. Biochemistry. 2001 Academic Article GET IT
Times cited: 46
A piece of the action. Genome biology. 2001 Academic Article GET IT
Winter, plague and pestilence. Genome biology. 2001 Academic Article GET IT
Times cited: 3
Design by necessity. Genome biology. 2001 Academic Article GET IT
Times cited: 2
Model behavior. Genome biology. 2001 Academic Article GET IT
Inhibition of the aminopeptidase from Aeromonas proteolytica by L-leucinephosphonic acid. Spectroscopic and crystallographic characterization of the transition state of peptide hydrolysis. Biochemistry. 2001 Academic Article GET IT
Times cited: 71
Protein misfolding and temperature up-shift cause G1 arrest via a common mechanism dependent on heat shock factor in Saccharomycescerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 2001 Academic Article GET IT
Times cited: 78
Location, location, location. Genome biology. 2001 Academic Article GET IT
Times cited: 1
The Rosetta stone. Genome biology. 2001 Academic Article GET IT
Times cited: 7
The slide rule and the calculator. Genome biology. 2001 Academic Article GET IT
Size doesn't matter. Genome biology. 2001 Academic Article GET IT
Times cited: 6
Homologuephobia. Genome biology. 2001 Academic Article GET IT
Times cited: 12
Structural basis of thermostability in hyperthermophilic proteins, or "there's more than one way to skin a cat". Methods in enzymology. 2001 Academic Article GET IT
Times cited: 130
Count me out. Genome biology. 2000 Academic Article GET IT
Times cited: 1
Seek and ye shall maybe find. Genome biology. 2000 Academic Article GET IT
TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation. Proceedings of the National Academy of Sciences of the United States of America. 2000 Academic Article GET IT
Times cited: 22
Perpetual motion of the worst kind. Genome biology. 2000 Academic Article GET IT
The dark side. Genome biology. 2000 Academic Article GET IT
Dog eat dogma. Genome biology. 2000 Academic Article GET IT
Times cited: 7
The grail problem. Genome biology. 2000 Academic Article GET IT
Times cited: 5
Crystal structure at 2.4 A resolution of Borrelia burgdorferi inosine 5'-monophosphate dehydrogenase: evidence of a substrate-induced hinged-lid motion by loop 6. Biochemistry. 2000 Academic Article GET IT
Times cited: 40
The catalytic pathway of cytochrome p450cam at atomic resolution. Science (New York, N.Y.). 2000 Academic Article GET IT
Times cited: 1219
Enzyme evolution. Design by necessity. Nature. 2000 Comment GET IT
Times cited: 18
Crystal structure of rabbit phosphoglucose isomerase, a glycolytic enzyme that moonlights as neuroleukin, autocrine motility factor, and differentiation mediator. Biochemistry. 2000 Academic Article GET IT
Times cited: 109
Observation of unstable species in enzyme-catalyzed transformations using protein crystallography. Current opinion in chemical biology. 2000 Review GET IT
Times cited: 49
The role of residues outside the active site: structural basis for function of C191 mutants of Escherichia coli aspartate aminotransferase. Protein engineering. 2000 Academic Article GET IT
Times cited: 29
Chemistry and biology. Proceedings of the National Academy of Sciences of the United States of America. 2000 Comment GET IT
Times cited: 28
Solvent mobility and the protein 'glass' transition. Nature structural biology. 2000 Academic Article GET IT
Times cited: 379
1-Butaneboronic acid binding to Aeromonas proteolytica aminopeptidase: a case of arrested development. Biochemistry. 1999 Academic Article GET IT
Times cited: 45
David Phillips and the origin of structural enzymology. Trends in biochemical sciences. 1999 Academic Article GET IT
Times cited: 4
Structure of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli, a key enzyme in the aspartate family of amino acid biosynthesis. Journal of molecular biology. 1999 Academic Article GET IT
Times cited: 60
Quantum enzymology. Tunnel vision. Nature. 1999 Comment GET IT
Times cited: 16
Preliminary crystallographic studies of a protease resistant botulinum neurotoxin associated protein Hn-33. Acta crystallographica. Section D, Biological crystallography. 1999 Academic Article GET IT
Times cited: 1
David Phillips (1924-99). Nature. 1999 Article GET IT
The role of water in the catalytic efficiency of triosephosphate isomerase. Biochemistry. 1999 Academic Article GET IT
Times cited: 46
Structure of a Michaelis complex analogue: propionate binds in the substrate carboxylate site of alanine racemase. Biochemistry. 1999 Academic Article GET IT
Times cited: 71
Evolution of an enzyme active site: the structure of a new crystal form of muconate lactonizing enzyme compared with mandelate racemase and enolase. Proceedings of the National Academy of Sciences of the United States of America. 1998 Academic Article GET IT
Times cited: 74
Crystal structures of L201A mutant of D-amino acid aminotransferase at 2.0 A resolution: implication of the structural role of Leu201 in transamination. Protein engineering. 1998 Academic Article GET IT
Times cited: 12
The crystal structure of benzoylformate decarboxylase at 1.6 A resolution: diversity of catalytic residues in thiamin diphosphate-dependent enzymes. Biochemistry. 1998 Academic Article GET IT
Times cited: 164
Crystallization and preliminary X-ray diffraction analysis of aspartate aminotransferase from Saccharomyces cerevisiae. Acta crystallographica. Section D, Biological crystallography. 1998 Academic Article GET IT
Times cited: 2
Adjustment of conformational flexibility is a key event in the thermal adaptation of proteins. Proceedings of the National Academy of Sciences of the United States of America. 1998 Academic Article GET IT
Times cited: 496
Crystal structure of Saccharomyces cerevisiae cytosolic aspartate aminotransferase. Protein science : a publication of the Protein Society. 1998 Academic Article GET IT
Times cited: 30
Inactivation and destruction of conserved Trp159 of Fe-superoxide dismutase from Porphyromonas gingivalis by hydrogen peroxide. European journal of biochemistry. 1998 Academic Article GET IT
Times cited: 34
Substrate inhibition of D-amino acid transaminase and protection by salts and by reduced nicotinamide adenine dinucleotide: isolation and initial characterization of a pyridoxo intermediate related to inactivation. Biochemistry. 1998 Academic Article GET IT
Times cited: 8
Immediate release of crystallographic data: a proposal. Science (New York, N.Y.). 1998 Letter GET IT
Times cited: 6
The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant. Biochemistry. 1997 Academic Article GET IT
Times cited: 59
Sequence and homology model of 3-isopropylmalate dehydrogenase from the psychrotrophic bacterium Vibrio sp. I5 suggest reasons for thermal instability. Protein engineering. 1997 Academic Article GET IT
Times cited: 40
Characterization of two crystal forms of 3-carboxy-cis,cis-muconate lactonizing enzyme from Pseudomonas putida. Acta crystallographica. Section D, Biological crystallography. 1997 Academic Article GET IT
Crystal structures of Escherichia coli and Salmonella typhimurium 3-isopropylmalate dehydrogenase and comparison with their thermophilic counterpart from Thermus thermophilus. Journal of molecular biology. 1997 Academic Article GET IT
Times cited: 130
A comparison between molecular dynamics and X-ray results for dissociated CO in myoglobin. Nature structural biology. 1997 Academic Article GET IT
Times cited: 80
Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins. Nature structural biology. 1997 Academic Article GET IT
Times cited: 127
Determination of the structure of alanine racemase from Bacillus stearothermophilus at 1.9-A resolution. Biochemistry. 1997 Academic Article GET IT
Times cited: 258
Purification, catalytic properties and thermostability of 3-isopropylmalate dehydrogenase from Escherichia coli. Biochimica et biophysica acta. 1997 Academic Article GET IT
Times cited: 24
The structural basis for pseudoreversion of the H95N lesion by the secondary S96P mutation in triosephosphate isomerase. Biochemistry. 1996 Academic Article GET IT
Times cited: 12
The ubiquitous cofactor NADH protects against substrate-induced inhibition of a pyridoxal enzyme. Protein science : a publication of the Protein Society. 1996 Academic Article GET IT
Times cited: 4
For medicinal purposes. Nature. 1996 Review GET IT
Times cited: 36
Engineering and design of blood substitutes. Current opinion in structural biology. 1996 Review GET IT
Times cited: 32
Not just your average structures. Nature structural biology. 1996 Article GET IT
Times cited: 24
Mechanism of the reaction catalyzed by mandelate racemase: structure and mechanistic properties of the D270N mutant. Biochemistry. 1996 Academic Article GET IT
Times cited: 62
Interaction of pyridoxal 5'-phosphate with tryptophan-139 at the subunit interface of dimeric D-amino acid transaminase. Biochemistry. 1996 Academic Article GET IT
Times cited: 9
Catalytic ability and stability of two recombinant mutants of D-amino acid transaminase involved in coenzyme binding. Protein science : a publication of the Protein Society. 1995 Academic Article GET IT
Times cited: 8
Use of a minimum perturbation approach to predict TIM mutant structures. Protein engineering. 1995 Academic Article GET IT
Times cited: 9
Cancer chemotherapy. Heavy metal revival. Nature. 1995 Comment GET IT
Times cited: 10
The structural basis for pseudoreversion of the E165D lesion by the secondary S96P mutation in triosephosphate isomerase depends on the positions of active site water molecules. Biochemistry. 1995 Academic Article GET IT
Times cited: 19
Revision of the amino-acid sequence of 3-isopropylmalate dehydrogenase from Salmonella typhimurium by means of X-ray crystallography. Gene. 1995 Academic Article GET IT
Times cited: 5
Structures of the apo- and the metal ion-activated forms of the diphtheria tox repressor from Corynebacterium diphtheriae. Proceedings of the National Academy of Sciences of the United States of America. 1995 Academic Article GET IT
Times cited: 82
Composition analysis of alpha-helices in thermophilic organisms. Protein engineering. 1995 Academic Article GET IT
Times cited: 45
Crystal structure of a D-amino acid aminotransferase: how the protein controls stereoselectivity. Biochemistry. 1995 Academic Article GET IT
Times cited: 154
Interaction of a peptidomimetic aminimide inhibitor with elastase. Science (New York, N.Y.). 1995 Academic Article GET IT
Times cited: 52
Purification and crystallization of benzoylformate decarboxylase. Protein science : a publication of the Protein Society. 1995 Academic Article GET IT
Times cited: 25
Design, synthesis, and characterization of a potent xylose isomerase inhibitor, D-threonohydroxamic acid, and high-resolution X-ray crystallographic structure of the enzyme-inhibitor complex. Biochemistry. 1995 Academic Article GET IT
Times cited: 58
Structural analysis of the active site of porcine pancreatic elastase based on the X-ray crystal structures of complexes with trifluoroacetyl-dipeptide-anilide inhibitors. Biochemistry. 1995 Academic Article GET IT
Times cited: 29
Mechanism of the reaction catalyzed by mandelate racemase: importance of electrophilic catalysis by glutamic acid 317. Biochemistry. 1995 Academic Article GET IT
Times cited: 77
Mechanism of the reaction catalyzed by mandelate racemase: structure and mechanistic properties of the K166R mutant. Biochemistry. 1995 Academic Article GET IT
Times cited: 71
A functionally diverse enzyme superfamily that abstracts the alpha protons of carboxylic acids. Science (New York, N.Y.). 1995 Academic Article GET IT
Times cited: 141
Crystallization and preliminary X-ray studies of the diphtheria Tox repressor from Corynebacterium diphtheriae. Journal of molecular biology. 1994 Academic Article GET IT
Times cited: 5
Expression, crystallization and preliminary crystallographic analysis of human carbonyl reductase. Journal of molecular biology. 1994 Academic Article GET IT
Times cited: 23
Biophysics. The little big bang. Nature. 1994 Comment GET IT
Times cited: 10
Direct structural observation of an acyl-enzyme intermediate in the hydrolysis of an ester substrate by elastase. Biochemistry. 1994 Academic Article GET IT
Times cited: 72
Analysis of two-residue turns in proteins. Journal of molecular biology. 1994 Academic Article GET IT
Times cited: 64
X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis. Biochemistry. 1994 Academic Article GET IT
Times cited: 113
Crystal structure of recombinant chicken triosephosphate isomerase-phosphoglycolohydroxamate complex at 1.8-A resolution. Biochemistry. 1994 Academic Article GET IT
Times cited: 90
Crystal structure of the K12M/G15A triosephosphate isomerase double mutant and electrostatic analysis of the active site. Biochemistry. 1994 Academic Article GET IT
Times cited: 44
Crystal structure of the mutant yeast triosephosphate isomerase in which the catalytic base glutamic acid 165 is changed to aspartic acid. Biochemistry. 1994 Academic Article GET IT
Times cited: 38
An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate. Biochemistry. 1994 Academic Article GET IT
Times cited: 150
Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme. Biochemistry. 1994 Academic Article GET IT
Times cited: 184
Isotopic exchange plus substrate and inhibition kinetics of D-xylose isomerase do not support a proton-transfer mechanism. Biochemistry. 1994 Academic Article GET IT
Times cited: 65
Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid. Biochemistry. 1994 Academic Article GET IT
Times cited: 66
Cloning, sequencing, and expression in Escherichia coli of the gene encoding a 45-kilodalton protein, elongation factor Tu, from Chlamydia trachomatis serovar F. Journal of bacteriology. 1994 Academic Article GET IT
Times cited: 18
The role of lysine 166 in the mechanism of mandelate racemase from Pseudomonas putida: mechanistic and crystallographic evidence for stereospecific alkylation by (R)-alpha-phenylglycidate. Biochemistry. 1994 Academic Article GET IT
Times cited: 112
Analogous inhibitors of elastase do not always bind analogously. Nature structural biology. 1994 Academic Article GET IT
Times cited: 94
Structure of the Mg(2+)-bound form of CheY and mechanism of phosphoryl transfer in bacterial chemotaxis. Biochemistry. 1993 Academic Article GET IT
Times cited: 197
A novel structural basis for membrane association of a protein: construction of a chimeric soluble mutant of (S)-mandelate dehydrogenase from Pseudomonas putida. Biochemistry. 1993 Academic Article GET IT
Times cited: 37
26-10 Fab-digoxin complex: affinity and specificity due to surface complementarity. Proceedings of the National Academy of Sciences of the United States of America. 1993 Academic Article GET IT
Times cited: 134
On the origin of enzymatic species. Trends in biochemical sciences. 1993 Review GET IT
Times cited: 112
Left-handed comments. Science (New York, N.Y.). 1992 Letter GET IT
Times cited: 1
Crystallization and preliminary crystallographic analysis of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli. Journal of molecular biology. 1992 Academic Article GET IT
Times cited: 3
Signal transduction. Fishing in Src-infested waters. Nature. 1992 Comment GET IT
Times cited: 7
On the other hand.. Science (New York, N.Y.). 1992 Comment GET IT
Times cited: 24
Crystalline ribonuclease A loses function below the dynamical transition at 220 K. Nature. 1992 Academic Article GET IT
Times cited: 506
Structure determination of turkey egg-white lysozyme using Laue diffraction data. Acta crystallographica. Section B, Structural science. 1992 Academic Article GET IT
Times cited: 26
Effects of temperature on protein structure and dynamics: X-ray crystallographic studies of the protein ribonuclease-A at nine different temperatures from 98 to 320 K. Biochemistry. 1992 Academic Article GET IT
Times cited: 350
Activity of crystalline turkey egg white lysozyme. Proteins. 1992 Academic Article GET IT
Times cited: 5
Viral proteases. Molecular metamorphosis. Nature. 1991 Comment GET IT
Times cited: 3
Mechanism of the reaction catalyzed by mandelate racemase. 2. Crystal structure of mandelate racemase at 2.5-A resolution: identification of the active site and possible catalytic residues. Biochemistry. 1991 Academic Article GET IT
Times cited: 143
Enzyme evolution. Déjà vu all over again. Nature. 1991 Comment GET IT
Times cited: 23
Observation of the light-triggered binding of pyrone to chymotrypsin by Laue x-ray crystallography. Proceedings of the National Academy of Sciences of the United States of America. 1991 Academic Article GET IT
Times cited: 47
Computer simulation and analysis of the reaction pathway of triosephosphate isomerase. Biochemistry. 1991 Academic Article GET IT
Times cited: 260
Structure of the triosephosphate isomerase-phosphoglycolohydroxamate complex: an analogue of the intermediate on the reaction pathway. Biochemistry. 1991 Academic Article GET IT
Times cited: 202
Three-dimensional structure of murine anti-p-azophenylarsonate Fab 36-71. 1. X-ray crystallography, site-directed mutagenesis, and modeling of the complex with hapten. Biochemistry. 1991 Academic Article GET IT
Times cited: 86
Three-dimensional structure of murine anti-p-azophenylarsonate Fab 36-71. 2. Structural basis of hapten binding and idiotypy. Biochemistry. 1991 Academic Article GET IT
Times cited: 41
Electrophilic catalysis in triosephosphate isomerase: the role of histidine-95. Biochemistry. 1991 Academic Article GET IT
Times cited: 125
Activity and structure of the active-site mutants R386Y and R386F of Escherichia coli aspartate aminotransferase. Biochemistry. 1991 Academic Article GET IT
Times cited: 47
The structure of iron superoxide dismutase from Pseudomonas ovalis complexed with the inhibitor azide. Protein engineering. 1990 Academic Article GET IT
Times cited: 31
Mandelate racemase and muconate lactonizing enzyme are mechanistically distinct and structurally homologous. Nature. 1990 Academic Article GET IT
Times cited: 110
Molecular dynamics simulations in biology. Nature. 1990 Review GET IT
Times cited: 791
The 2.1-A resolution structure of iron superoxide dismutase from Pseudomonas ovalis. Biochemistry. 1990 Academic Article GET IT
Times cited: 141
Anatomy of a conformational change: hinged "lid" motion of the triosephosphate isomerase loop. Science (New York, N.Y.). 1990 Academic Article GET IT
Times cited: 281
Photolysis and deacylation of inhibited chymotrypsin. Biochemistry. 1990 Academic Article GET IT
Times cited: 43
Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis. The EMBO journal. 1990 Academic Article GET IT
Times cited: 967
Cystic fibrosis. A transport problem?. Nature. 1990 Comment GET IT
Times cited: 26
Crystallographic analysis of the complex between triosephosphate isomerase and 2-phosphoglycolate at 2.5-A resolution: implications for catalysis. Biochemistry. 1990 Academic Article GET IT
Times cited: 234
Structure of yeast triosephosphate isomerase at 1.9-A resolution. Biochemistry. 1990 Academic Article GET IT
Times cited: 254
The evolution of alpha/beta barrel enzymes. Trends in biochemical sciences. 1990 Review GET IT
Times cited: 420
Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis. Nature. 1990 Academic Article GET IT
Times cited: 420
Structure and activity of two photoreversible cinnamates bound to chymotrypsin. Biochemistry. 1990 Academic Article GET IT
Times cited: 58
Crystal structure of the antigen-binding fragment of the murine anti-arsonate monoclonal antibody 36-71 at 2.9-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 1990 Academic Article GET IT
Times cited: 23
Restructuring catalysis in the mandelate pathway. Biochemical Society symposium. 1990 Academic Article GET IT
Times cited: 1
Site-directed mutagenesis applied to glucose isomerase from Streptomyces violaceoniger and Streptomyces olivochromogenes. Annals of the New York Academy of Sciences. 1990 Academic Article GET IT
Times cited: 5
Transition-state analogues in protein crystallography: probes of the structural source of enzyme catalysis. Annual review of biochemistry. 1990 Review GET IT
Times cited: 69
Second structure determinations. Protein engineering. 1989 Editorial Article GET IT
Effects of D-serine on bacterial D-amino acid transaminase: accumulation of an intermediate and inactivation of the enzyme. Biochemistry. 1989 Academic Article GET IT
Times cited: 14
Crystallographic studies of the mechanism of xylose isomerase. Biochemistry. 1989 Academic Article GET IT
Times cited: 109
Activity and spectroscopic properties of bacterial D-amino acid transaminase after multiple site-directed mutagenesis of a single tryptophan residue. Biochemistry. 1989 Academic Article GET IT
Times cited: 21
Site-directed mutagenesis of the cysteinyl residues and the active-site serine residue of bacterial D-amino acid transaminase. Biochemistry. 1989 Academic Article GET IT
Characterization of crystals of xylose isomerase from Streptomyces violaceoniger. The Journal of biological chemistry. 1988 Academic Article GET IT
Times cited: 8
The refined crystal structure of subtilisin Carlsberg at 2.5 A resolution. Protein engineering. 1988 Academic Article GET IT
Times cited: 108
A structure of sperm whale myoglobin at a nitrogen gas pressure of 145 atmospheres. Biochemistry. 1988 Academic Article GET IT
Times cited: 23
Triosephosphate isomerase: removal of a putatively electrophilic histidine residue results in a subtle change in catalytic mechanism. Biochemistry. 1988 Academic Article GET IT
Times cited: 127
Preliminary x-ray data on crystals of mandelate racemase. The Journal of biological chemistry. 1988 Academic Article GET IT
Times cited: 11
Weakly polar interactions in proteins. Advances in protein chemistry. 1988 Review GET IT
Times cited: 803
X-ray Laue diffraction from crystals of xylose isomerase. Proceedings of the National Academy of Sciences of the United States of America. 1988 Academic Article GET IT
Times cited: 36
Ribonuclease structure and catalysis: crystal structure of sulfate-free native ribonuclease A at 1.5-A resolution. Biochemistry. 1987 Academic Article GET IT
Times cited: 51
The 3.0 A crystal structure of xylose isomerase from Streptomyces olivochromogenes. Protein engineering. 1987 Academic Article GET IT
Times cited: 50
X-ray crystallographic studies of the alanine-specific racemase from Bacillus stearothermophilus. Overproduction, crystallization, and preliminary characterization. The Journal of biological chemistry. 1987 Academic Article GET IT
Times cited: 30
Molecular mechanics modeling of oligonucleotide adducts of the antitumor drug cis-diamminedichloroplatinum(II). Biopolymers. 1987 Academic Article GET IT
Times cited: 70
Preliminary X-ray data for a D-amino acid amino-transferase from a novel thermophilic Bacillus. Journal of molecular biology. 1987 Academic Article GET IT
Times cited: 9
Subunit interface of triosephosphate isomerase: site-directed mutagenesis and characterization of the altered enzyme. Biochemistry. 1987 Academic Article GET IT
Times cited: 60
Control of oligomeric enzyme thermostability by protein engineering. Proceedings of the National Academy of Sciences of the United States of America. 1987 Academic Article GET IT
Times cited: 115
Thermal expansion of a protein. Biochemistry. 1987 Academic Article GET IT
Times cited: 205
Crystallography and site-directed mutagenesis of yeast triosephosphate isomerase: what can we learn about catalysis from a "simple" enzyme?. Cold Spring Harbor symposia on quantitative biology. 1987 Academic Article GET IT
Times cited: 48
Estimation of uncertainties in X-ray refinement results by use of perturbed structures. Proteins. 1987 Academic Article GET IT
Times cited: 20
X-ray structure and refinement of carbon-monoxy (Fe II)-myoglobin at 1.5 A resolution. Journal of molecular biology. 1986 Academic Article GET IT
Times cited: 511
Amino-aromatic interactions in proteins. FEBS letters. 1986 Academic Article GET IT
Times cited: 706
Effect of anisotropy and anharmonicity on protein crystallographic refinement. An evaluation by molecular dynamics. Journal of molecular biology. 1986 Academic Article GET IT
Times cited: 128
Study of protein dynamics by X-ray diffraction. Methods in enzymology. 1986 Academic Article GET IT
Times cited: 147
Aromatic-aromatic interaction: a mechanism of protein structure stabilization. Science (New York, N.Y.). 1985 Review GET IT
Times cited: 2263
Diffraction methods for biological macromolecules. Flow cell construction and use. Methods in enzymology. 1985 Academic Article GET IT
Times cited: 23
Mapping protein dynamics by X-ray diffraction. Progress in biophysics and molecular biology. 1985 Review GET IT
Times cited: 119
Preparation of isomorphous heavy-atom derivatives. Methods in enzymology. 1985 Academic Article GET IT
Times cited: 60
Preliminary X-ray crystallographic studies of pig kidney fructose-1,6-bisphosphatase. The Journal of biological chemistry. 1984 Academic Article GET IT
Times cited: 3
Cavities in proteins: structure of a metmyoglobin-xenon complex solved to 1.9 A. Biochemistry. 1984 Academic Article GET IT
Times cited: 461
Probing the catalytic mechanism of yeast triose phosphate isomerase by site-specific mutagenesis. Biochemical Society transactions. 1984 Academic Article GET IT
Times cited: 15
Reaction of myoglobin with phenylhydrazine: a molecular doorstop. Biochemistry. 1984 Academic Article GET IT
Times cited: 167
Fluctuations in protein structure from X-ray diffraction. Annual review of biophysics and bioengineering. 1984 Review GET IT
Times cited: 203
Proteins at work: "stop-action" pictures at subzero temperatures. Advances in protein chemistry. 1984 Review GET IT
Times cited: 102
The x-ray structure of the periplasmic galactose binding protein from Salmonella typhimurium at 3.0-A resolution. The Journal of biological chemistry. 1983 Academic Article GET IT
Times cited: 39
Structure of iron superoxide dismutase from Pseudomonas ovalis at 2.9-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 1983 Academic Article GET IT
Times cited: 104
The introduction of specific sites for heavy metal binding in a crystalline protein. The Journal of biological chemistry. 1983 Academic Article GET IT
Times cited: 7
Structure of oxidized flavodoxin from Anacystis nidulans. Journal of molecular biology. 1983 Academic Article GET IT
Times cited: 83
The iron content of iron superoxide dismutase: determination by anomalous scattering. Proceedings of the Royal Society of London. Series B, Biological sciences. 1983 Academic Article GET IT
Times cited: 2
Crystallization of the Fab fragment of a monoclonal anti-digoxin antibody and its complex with digoxin. Journal of molecular biology. 1983 Academic Article GET IT
Times cited: 13
Studies of calmodulin structure: laser raman spectroscopy of biomolecules. Biochemistry. 1983 Academic Article GET IT
Times cited: 17
The role of mobility in the substrate binding and catalytic machinery of enzymes. Ciba Foundation symposium. 1983 Academic Article GET IT
Times cited: 74
Preliminary X-ray data for the ribose binding protein from Salmonella typhimurium. Journal of molecular biology. 1982 Academic Article GET IT
Times cited: 2
Conformational substates in a protein: structure and dynamics of metmyoglobin at 80 K. Proceedings of the National Academy of Sciences of the United States of America. 1982 Academic Article GET IT
Times cited: 229
Crystallization and preliminary X-ray investigation of avidin. European journal of biochemistry. 1982 Academic Article GET IT
Times cited: 14
On the three-dimensional structure and catalytic mechanism of triose phosphate isomerase. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 1981 Review GET IT
Times cited: 204
Preliminary x-ray data for the galactose binding protein from Salmonella typhimurium. Journal of molecular biology. 1981 Academic Article GET IT
Times cited: 1
Crystallization of yeast triose phosphate isomerase from polyethylene glycol. Protein crystal formation following phase separation. The Journal of biological chemistry. 1981 Academic Article GET IT
Times cited: 19
X-ray cryoenzymology. Advances in enzymology and related areas of molecular biology. 1981 Review GET IT
Times cited: 39
Structural dynamics of liganded myoglobin. Biophysical journal. 1980 Academic Article GET IT
Times cited: 57
Temperature-dependent X-ray diffraction as a probe of protein structural dynamics. Nature. 1979 Academic Article GET IT
Times cited: 902
Structure and function of snake venom curarimimetic neurotoxins. Molecular pharmacology. 1978 Academic Article GET IT
Times cited: 52
On the protein crystal chemistry of chloroplatinite ions: general principles and interactions with triose phosphate isomerase. Journal of molecular biology. 1978 Academic Article GET IT
Times cited: 20
Molecular graphics: application to the structure determination of a snake venom neurotoxin. Science (New York, N.Y.). 1977 Academic Article GET IT
Times cited: 28
Protein sequencing by computer graphics. Biochimica et biophysica acta. 1977 Academic Article GET IT
Times cited: 7
Three-dimensional structure of neurotoxin a from venom of the Philippines sea snake. Proceedings of the National Academy of Sciences of the United States of America. 1977 Academic Article GET IT
Times cited: 80
New high pH crystal forms of ribonucleases A and S. Journal of molecular biology. 1976 Academic Article GET IT
Times cited: 10
Crystal structure of elastase-substrate complex at -- 55 degrees C. Nature. 1976 Academic Article GET IT
Times cited: 73
The crystal structure of a post-synaptic neurotoxin from sea snake at A resolution. FEBS letters. 1976 Academic Article GET IT
Times cited: 200
The structure of subtilopeptidase A. I. X-ray crystallographic data. Journal of molecular biology. 1976 Academic Article GET IT
Times cited: 14
Atomic coordinates for triose phosphate isomerase from chicken muscle. Biochemical and biophysical research communications. 1976 Academic Article GET IT
Times cited: 61
Protein crystallography at sub-zero temperatures: cryo-protective mother liquors for protein crystals. Journal of molecular biology. 1975 Academic Article GET IT
Times cited: 114
Protein crystallography at sub-zero temperatures: lysozyme-substrate complexes in cooled mixed solvents. Journal of molecular biology. 1975 Academic Article GET IT
Times cited: 54
Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5 angstrom resolution using amino acid sequence data. Nature. 1975 Academic Article GET IT
Times cited: 601
Crystallographic studies of chicken triose phosphate isomerase. Cold Spring Harbor symposia on quantitative biology. 1972 Academic Article GET IT
Times cited: 16
Proton magnetic resonance spectrum of polywater. Science (New York, N.Y.). 1970 Academic Article GET IT
Times cited: 16

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Background

education and training

D.Phil., Oxford University (United Kingdom) 1973
B.A., Princeton University 1970

Contact

full name

Gregory Petsko

primary email

gpetsko@med.cornell.edu

VIVO Weill Cornell Medical College

Gregory Petsko Adjunct Professor of Neuroscience

Publications

selected publications

Background

education and training

Contact

full name

primary email