Spreading depolarization: a possible new culprit in the delayed cerebral ischemia of subarachnoid hemorrhage. Review uri icon

Overview

abstract

  • Aneurysmal subarachnoid hemorrhage (SAH) is a devastating disease with a high mortality and morbidity rate. Gradual improvements have been made in the reduction of mortality rates associated with the disease during the last 30 years. However, delayed cerebral ischemia (DCI), the major delayed complication of SAH, remains a significant contributor to mortality and morbidity despite substantial research and clinical efforts. During the last several years, the predominant role of cerebral vasospasm, the long-accepted etiologic factor behind DCI, has been questioned. It is now becoming increasingly clear that the pathophysiology underlying DCI is multifactorial. Cortical spreading depression is emerging as a likely factor in this complex web of pathologic changes after SAH. Understanding its role after SAH and its relationship with the other pathologic processes such as vasospasm, microcirculatory dysfunction, and microemboli will be vital to the development of new therapeutic approaches to reduce DCI and improve the clinical outcome of the disease.

publication date

  • September 13, 2010

Research

keywords

  • Brain Ischemia
  • Cortical Spreading Depression
  • Subarachnoid Hemorrhage

Identity

PubMed Central ID

  • PMC3998646

Scopus Document Identifier

  • 78651280074

Digital Object Identifier (DOI)

  • 10.1111/j.1600-0404.2010.01363.x

PubMed ID

  • 20837823

Additional Document Info

volume

  • 68

issue

  • 1