Engaging neuroscience to advance translational research in brain barrier biology. Review uri icon

Overview

abstract

  • The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and--when barrier integrity is impaired--in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.

publication date

  • March 1, 2011

Research

keywords

  • Blood-Brain Barrier
  • Nervous System Diseases
  • Neurosciences
  • Translational Research, Biomedical

Identity

PubMed Central ID

  • PMC3335275

Scopus Document Identifier

  • 79951922143

Digital Object Identifier (DOI)

  • 10.1038/nrn2995

PubMed ID

  • 21331083

Additional Document Info

volume

  • 12

issue

  • 3