Ca(2+) signaling, genes and the cell cycle. Review uri icon

Overview

abstract

  • Changes in the concentration and spatial distribution of Ca(2+) ions in the cytoplasm constitute a ubiquitous intracellular signaling module in cellular physiology. With the advent of Ca(2+) dyes that allow direct visualization of Ca(2+) transients, combined with powerful experimental tools such as electrophysiological recordings, intracellular Ca(2+) transients have been implicated in practically every aspect of cellular physiology, including cellular proliferation. Ca(2+) signals are associated with different phases of the cell cycle and interfering with Ca(2+) signaling or downstream pathways often disrupts progression of the cell cycle. Although there exists a dependence between Ca(2+) signals and the cell cycle the mechanisms involved are not well defined and given the cross-talk between Ca(2+) and other signaling modules, it is difficult to assess the exact role of Ca(2+) signals in cell cycle progression. Two exceptions however, include fertilization and T-cell activation, where well-defined roles for Ca(2+) signals in mediating progression through specific stages of the cell cycle have been clearly established. In the case of T-cell activation Ca(2+) regulates entry into the cell cycle through the induction of gene transcription.

publication date

  • May 1, 2011

Research

keywords

  • Calcium Signaling
  • Cell Cycle

Identity

Scopus Document Identifier

  • 79958210180

Digital Object Identifier (DOI)

  • 10.1016/j.ceca.2011.05.004

PubMed ID

  • 21809493

Additional Document Info

volume

  • 49

issue

  • 5