Machaca, Khaled

Publications

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selected publications

STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration. Cell calcium. 2023 Academic Article GET IT
SOCE as a regulator of neuronal activity. The Journal of physiology. 2023 Review GET IT
Selective modulation of gene expression in activated normal human peripheral blood mononuclear cells by store-operated calcium entry blocker BTP2. Research square. 2023 Article GET IT
Times cited: 515
STAT1- and NFAT-independent amplification of purinoceptor function integrates cellular senescence with interleukin-6 production in preadipocytes. British journal of pharmacology. 2022 Academic Article GET IT
Chronic reduction of store operated Ca²⁺ entry is viable therapeutically but is associated with cardiovascular complications. The Journal of physiology. 2022 Academic Article GET IT
Times cited: 3
Lipid Signaling During Gamete Maturation. Frontiers in cell and developmental biology. 2022 Review GET IT
Times cited: 237
The STIM1 Phosphorylation Saga. Cell calcium. 2022 Review GET IT
Times cited: 3
The QChip1 knowledgebase and microarray for precision medicine in Qatar. NPJ genomic medicine. 2022 Academic Article GET IT
Times cited: 2
A longer isoform of Stim1 is a negative SOCE regulator but increases cAMP-modulated NFAT signaling. EMBO reports. 2021 Academic Article GET IT
Times cited: 7
Phosphorylation of STIM1 at ERK/CDK sites is dispensable for cell migration and ER partitioning in mitosis. Cell calcium. 2021 Academic Article GET IT
Times cited: 4
Store Operated Calcium Entry in Cell Migration and Cancer Metastasis. Cells. 2021 Review GET IT
Times cited: 16
Native SOCE complexes: Small but mighty?. Cell calcium. 2021 Academic Article GET IT
Times cited: 1
Novel ORAI1 Mutation Disrupts Channel Trafficking Resulting in Combined Immunodeficiency. 2021 GET IT
Times cited: 2
Correction: Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2. PLoS biology. 2021 Article GET IT
Times cited: 1
The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis. Scientific reports. 2021 Academic Article GET IT
Times cited: 2
Multifunctional rhodamine B appended ROMP derived fluorescent probe detects Al³⁺ and selectively labels lysosomes in live cells. Scientific reports. 2020 Academic Article GET IT
Times cited: 8
Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2. PLoS biology. 2020 Academic Article GET IT
Times cited: 7
L-type Ca²⁺ channel blockers promote vascular remodeling through activation of STIM proteins. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 29
Ca²⁺ signaling and lipid transfer 'pas a deux' at ER-PM contact sites orchestrate cell migration. Cell calcium. 2020 Review GET IT
Times cited: 5
miRNA-dependent regulation of STIM1 expression in breast cancer. Scientific reports. 2019 Academic Article GET IT
Times cited: 6
Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca²⁺ influx in mitosis. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 19
Synthesis of TPEN variants to improve cancer cells selective killing capacity. Bioorganic chemistry. 2019 Academic Article GET IT
Times cited: 5
Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity. The Journal of biological chemistry. 2019 Academic Article GET IT
Times cited: 26
IP₃ receptors and store-operated Ca²⁺ entry: a license to fill. Current opinion in cell biology. 2018 Review GET IT
Times cited: 23
The CCT chaperonin is a novel regulator of Ca²⁺ signaling through modulation of Orai1 trafficking. Science advances. 2018 Academic Article GET IT
Times cited: 14
Spatially restricted subcellular Ca²⁺ signaling downstream of store-operated calcium entry encoded by a cortical tunneling mechanism. Scientific reports. 2018 Academic Article GET IT
Times cited: 8
Ion Channel Function During Oocyte Maturation and Fertilization. Frontiers in cell and developmental biology. 2018 Review GET IT
Times cited: 14
The VLDL receptor regulates membrane progesterone receptor trafficking and non-genomic signaling. Journal of cell science. 2018 Academic Article GET IT
Times cited: 6
Transition metal dependent regulation of the signal transduction cascade driving oocyte meiosis. Journal of cellular physiology. 2017 Academic Article GET IT
Times cited: 1
Effects of Hyperglycemia on Vascular Smooth Muscle Ca²⁺ Signaling. BioMed research international. 2017 Academic Article GET IT
Times cited: 11
Ca²⁺ tunnelling through the ER lumen as a mechanism for delivering Ca²⁺ entering via store-operated Ca²⁺ channels to specific target sites. The Journal of physiology. 2017 Review GET IT
Times cited: 38
Coculturing with endothelial cells promotes in vitro maturation and electrical coupling of human embryonic stem cell-derived cardiomyocytes. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2017 Academic Article GET IT
Times cited: 27
Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells. Cancer biology & therapy. 2016 Academic Article GET IT
Times cited: 11
Store-Operated Ca²⁺ Entry in Oocytes Modulate the Dynamics of IP₃ -Dependent Ca²⁺ Release From Oscillatory to Tonic. Journal of cellular physiology. 2016 Academic Article GET IT
Times cited: 13
Xenopus Oocyte As a Model System to Study Store-Operated Ca(2+) Entry (SOCE). Frontiers in cell and developmental biology. 2016 Academic Article GET IT
Times cited: 105
The Ca2+-activated Cl- channel Ano1 controls microvilli length and membrane surface area in the oocyte. Journal of cell science. 2016 Academic Article GET IT
Times cited: 17
Release from Xenopus oocyte prophase I meiotic arrest is independent of a decrease in cAMP levels or PKA activity. Development (Cambridge, England). 2016 Academic Article GET IT
Times cited: 15
A novel approach to the expression and purification of recombinant Xenopus Cdc25C. Protein expression and purification. 2015 Academic Article GET IT
Times cited: 2
The Role of Flexible Loops in Folding, Trafficking and Activity of Equilibrative Nucleoside Transporters. PloS one. 2015 Academic Article GET IT
Times cited: 12
A STIM1-dependent 'trafficking trap' mechanism regulates Orai1 plasma membrane residence and Ca²⁺ influx levels. Journal of cell science. 2015 Academic Article GET IT
Times cited: 32
Role for endocytosis of a constitutively active GPCR (GPR185) in releasing vertebrate oocyte meiotic arrest. Developmental biology. 2014 Academic Article GET IT
Times cited: 8
Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species. BMC cancer. 2014 Academic Article GET IT
Times cited: 77
Mid-range Ca2+ signalling mediated by functional coupling between store-operated Ca2+ entry and IP3-dependent Ca2+ release. Nature communications. 2014 Academic Article GET IT
Times cited: 44
The role of IP3 receptor channel clustering in Ca2+ wave propagation during oocyte maturation. Progress in molecular biology and translational science. 2014 Academic Article GET IT
Times cited: 7
The Xenopus TRPV6 homolog encodes a Mg(2+) -permeant channel that is inhibited by interaction with TRPC1. Journal of cellular physiology. 2013 Academic Article GET IT
Times cited: 12
Understanding fertilization through intracytoplasmic sperm injection (ICSI). Cell calcium. 2013 Review GET IT
Times cited: 97
Inositol 1,4,5-trisphosphate (IP3) receptor up-regulation in hypertension is associated with sensitization of Ca2+ release and vascular smooth muscle contractility. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 37
Intramolecular shielding maintains the ER Ca²⁺ sensor STIM1 in an inactive conformation. Journal of cell science. 2013 Academic Article GET IT
Times cited: 44
Polymorphism in endothelial connexin40 enhances sensitivity to intraluminal pressure and increases arterial stiffness. Arteriosclerosis, thrombosis, and vascular biology. 2013 Academic Article GET IT
Times cited: 24
Downregulation of store-operated Ca2+ entry during mammalian meiosis is required for the egg-to-embryo transition. Journal of cell science. 2013 Academic Article GET IT
Times cited: 23
Egg activation and the egg-to-embryo transition. Preface. Cell calcium. 2013 Article GET IT
Times cited: 1
How to make a good egg!: The need for remodeling of oocyte Ca(2+) signaling to mediate the egg-to-embryo transition. Cell calcium. 2012 Review GET IT
Times cited: 27
Phosphorylation of the rat Ins(1,4,5)P₃ receptor at T930 within the coupling domain decreases its affinity to Ins(1,4,5)P₃. Channels (Austin, Tex.). 2012 Academic Article GET IT
Times cited: 6
STIM and Orai in cellular proliferation and division. Frontiers in bioscience (Elite edition). 2012 Review GET IT
Times cited: 32
Endoplasmic reticulum remodeling tunes IP₃-dependent Ca²+ release sensitivity. PloS one. 2011 Academic Article GET IT
Times cited: 21
Ca(2+) signaling, genes and the cell cycle. Cell calcium. 2011 Review GET IT
Times cited: 44
Role of the STIM1 C-terminal domain in STIM1 clustering. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 23
Ca(2+) signaling, genes and the cell cycle. Cell calcium. 2010 Review GET IT
Times cited: 41
Constitutive recycling of the store-operated Ca2+ channel Orai1 and its internalization during meiosis. The Journal of cell biology. 2010 Academic Article GET IT
Times cited: 106
Regulation of store-operated Ca2+ entry during the cell cycle. Journal of cell science. 2010 Academic Article GET IT
Times cited: 24
Orai1 internalization and STIM1 clustering inhibition modulate SOCE inactivation during meiosis. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 107
Kinase-dependent regulation of inositol 1,4,5-trisphosphate-dependent Ca2+ release during oocyte maturation. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 30
Internalization of plasma membrane Ca2+-ATPase during Xenopus oocyte maturation. Developmental biology. 2008 Academic Article GET IT
Times cited: 25
Ca2+ homeostasis regulates Xenopus oocyte maturation. Biology of reproduction. 2007 Academic Article GET IT
Times cited: 20
Ca2+ signaling differentiation during oocyte maturation. Journal of cellular physiology. 2007 Review GET IT
Times cited: 71
Zinc regulates the ability of Cdc25C to activate MPF/cdk1. Journal of cellular physiology. 2007 Academic Article GET IT
Times cited: 29
Vesicular traffic at the cell membrane regulates oocyte meiotic arrest. Development (Cambridge, England). 2007 Academic Article GET IT
Times cited: 24
Modeling Ca2+ signaling differentiation during oocyte maturation. Cell calcium. 2007 Academic Article GET IT
Times cited: 42
Calcium signaling differentiation during Xenopus oocyte maturation. Developmental biology. 2005 Academic Article GET IT
Times cited: 53
RNA interference is an antiviral defence mechanism in Caenorhabditis elegans. Nature. 2005 Academic Article GET IT
Times cited: 257
Rabphilin localizes with the cell actin cytoskeleton and stimulates association of granules with F-actin cross-linked by {alpha}-actinin. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 18
Increased sensitivity and clustering of elementary Ca2+ release events during oocyte maturation. Developmental biology. 2004 Academic Article GET IT
Times cited: 46
Ca(2+)(cyt) negatively regulates the initiation of oocyte maturation. The Journal of cell biology. 2004 Academic Article GET IT
Times cited: 45
Ca2+-calmodulin-dependent protein kinase II potentiates store-operated Ca2+ current. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 29
Endoplasmic reticulum Ca(2+) signaling and calpains mediate renal cell death. Cell death and differentiation. 2002 Academic Article GET IT
Times cited: 48
Induction of maturation-promoting factor during Xenopus oocyte maturation uncouples Ca(2+) store depletion from store-operated Ca(2+) entry. The Journal of cell biology. 2002 Academic Article GET IT
Times cited: 81
Store-operated calcium entry inactivates at the germinal vesicle breakdown stage of Xenopus meiosis. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 67
Adenophostin A and inositol 1,4,5-trisphosphate differentially activate Cl- currents in Xenopus oocytes because of disparate Ca2+ release kinetics. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 20
Reversible Ca gradients between the subplasmalemma and cytosol differentially activate Ca-dependent Cl currents. The Journal of general physiology. 1999 Academic Article GET IT
Times cited: 37
Asymmetrical distribution of Ca-activated Cl channels in Xenopus oocytes. Biophysical journal. 1998 Academic Article GET IT
Times cited: 43
The Caenorhabditis elegans spe-5 gene is required for morphogenesis of a sperm-specific organelle and is associated with an inherent cold-sensitive phenotype. Genetics. 1997 Academic Article GET IT
Times cited: 15
Effects of adenophostin-A and inositol-1,4,5-trisphosphate on Cl- currents in Xenopus laevis oocytes. Molecular pharmacology. 1997 Academic Article GET IT
Times cited: 30
A novel chloride channel localizes to Caenorhabditis elegans spermatids and chloride channel blockers induce spermatid differentiation. Developmental biology. 1996 Academic Article GET IT
Times cited: 51
Analysis of thymic lymphocyte apoptosis using in vitro techniques. Developmental and comparative immunology. 1993 Academic Article GET IT
Times cited: 14
Characterization of apoptosis-like endonuclease activity in avian thymocytes. Biology of the cell. 1992 Academic Article GET IT
Times cited: 11

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Research

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Co-investigator Network

Funding awarded

Physiological association between diabetes mellitus and cardiac arrhythmia awarded by Qatar Foundation Principal Investigator 2020 - 2024

Targeting membrane progesterone receptors to improve insulin resistance awarded by Qatar Foundation Co-Investigator 2021 - 2024

Unlocking precision medicine potential through functional genomic studies in the diagnosis of inherited immunodeficiency diseases awarded by Qatar National Research Fund Principal Investigator Subaward 2021 - 2023

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Background

education and training

Ph.D., Emory University 1996
M.S., University of Georgia 1992
B.S., American University of Beirut (Lebanon) 1990

Contact

full name

Khaled Machaca

primary email

khm2002@qatar-med.cornell.edu

VIVO Weill Cornell Medical College

Khaled Machaca Senior Associate Dean for Research

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email