Control of inflammation by integration of environmental cues by regulatory T cells. Review uri icon

Overview

abstract

  • Tregs have been implicated in control of homeostasis in the immune system and beyond. These cells restrain inflammatory responses to self antigens, commensal microorganisms, allergens, and pathogens and adapt their homeostatic and functional capabilities to a particular environment. In this review, we discuss a general model of integration of environmental cues by Tregs in which specialized Treg homeostatic, migratory, and suppression programs are established in dynamically changing inflammatory environments by maintaining an optimal threshold of activation of transcription factors involved in regulation of the corresponding type of effector immune responses.

publication date

  • March 1, 2013

Research

keywords

  • Inflammation
  • T-Lymphocytes, Regulatory

Identity

PubMed Central ID

  • PMC3582113

Scopus Document Identifier

  • 84874608992

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2010.08.012

PubMed ID

  • 23454755

Additional Document Info

volume

  • 123

issue

  • 3