Efficacy of nitazoxanide against clinical isolates of Mycobacterium tuberculosis. Academic Article uri icon

Overview

abstract

  • Nitazoxanide (NTZ) has bactericidal activity against the H37Rv laboratory strain of Mycobacterium tuberculosis with a MIC of 16 μg/ml. However, its efficacy against clinical isolates of M. tuberculosis has not been determined. We found that NTZ's MIC against 50 clinical isolates ranged from 12 to 28 μg/ml with a median of 16 μg/ml and was unaffected by resistance to first- or second-line antituberculosis drugs or a diversity of spoligotypes.

publication date

  • March 18, 2013

Research

keywords

  • Antitubercular Agents
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis
  • Thiazoles

Identity

PubMed Central ID

  • PMC3716123

Scopus Document Identifier

  • 84877866499

Digital Object Identifier (DOI)

  • 10.1371/journal.ppat.1002691

PubMed ID

  • 23507275

Additional Document Info

volume

  • 57

issue

  • 6