PTPN22 in autoimmunity: different cell and different way. uri icon

Overview

abstract

  • The tyrosine phosphatase PTPN22 regulates T cell receptor signaling. In this issue of Immunity, Wang et al. (2013) show that in myeloid cells PTPN22 potentiates TLR-induced type I interferon production and that autoimmunity-associated allele PTPN22W encodes a reduced-function variant.

publication date

  • July 25, 2013

Research

keywords

  • Autoimmunity
  • Immunity
  • Interferon Type I
  • Protein Tyrosine Phosphatase, Non-Receptor Type 22
  • Toll-Like Receptors

Identity

PubMed Central ID

  • PMC3785409

Scopus Document Identifier

  • 84880713993

Digital Object Identifier (DOI)

  • 10.1016/j.immuni.2013.07.007

PubMed ID

  • 23890067

Additional Document Info

volume

  • 39

issue

  • 1