Mechanisms of vancomycin resistance in Staphylococcus aureus. Review uri icon

Overview

abstract

  • Vancomycin is a glycopeptide antibiotic used for the treatment of Gram-positive bacterial infections. Traditionally, it has been used as a drug of last resort; however, clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) strains with decreased susceptibility to vancomycin (vancomycin intermediate-resistant S. aureus [VISA]) and more recently with high-level vancomycin resistance (vancomycin-resistant S. aureus [VRSA]) have been described in the clinical literature. The rare VRSA strains carry transposon Tn1546, acquired from vancomycin-resistant Enterococcus faecalis, which is known to alter cell wall structure and metabolism, but the resistance mechanisms in VISA isolates are less well defined. Herein, we review selected mechanistic aspects of resistance in VISA and summarize biochemical studies on cell wall synthesis in a VRSA strain. Finally, we recapitulate a model that integrates common mechanistic features of VRSA and VISA strains and is consistent with the mode of action of vancomycin.

publication date

  • July 1, 2014

Research

keywords

  • Staphylococcus aureus
  • Vancomycin Resistance

Identity

PubMed Central ID

  • PMC4071404

Scopus Document Identifier

  • 84903772231

Digital Object Identifier (DOI)

  • 10.1128/AAC.00431-07

PubMed ID

  • 24983424

Additional Document Info

volume

  • 124

issue

  • 7