Unraveling the clonal hierarchy of somatic genomic aberrations. Academic Article uri icon

Overview

abstract

  • Defining the chronology of molecular alterations may identify milestones in carcinogenesis. To unravel the temporal evolution of aberrations from clinical tumors, we developed CLONET, which upon estimation of tumor admixture and ploidy infers the clonal hierarchy of genomic aberrations. Comparative analysis across 100 sequenced genomes from prostate, melanoma, and lung cancers established diverse evolutionary hierarchies, demonstrating the early disruption of tumor-specific pathways. The analyses highlight the diversity of clonal evolution within and across tumor types that might be informative for risk stratification and patient selection for targeted therapies. CLONET addresses heterogeneous clinical samples seen in the setting of precision medicine.

publication date

  • August 26, 2014

Research

keywords

  • Adenocarcinoma
  • Clonal Evolution
  • Computational Biology
  • Lung Neoplasms
  • Melanoma
  • Prostatic Neoplasms

Identity

PubMed Central ID

  • PMC4167267

Scopus Document Identifier

  • 84964314022

Digital Object Identifier (DOI)

  • 10.1093/bioinformatics/btp579

PubMed ID

  • 25160065

Additional Document Info

volume

  • 15

issue

  • 8