Multiple sclerosis lesion geometry in quantitative susceptibility mapping (QSM) and phase imaging. Academic Article uri icon

Overview

abstract

  • PURPOSE: To demonstrate the phase and quantitative susceptibility mapping (QSM) patterns created by solid and shell spatial distributions of magnetic susceptibility in multiple sclerosis (MS) lesions. MATERIALS AND METHODS: Numerical simulations and experimental phantoms of solid- and shell-shaped magnetic susceptibility sources were used to generate magnitude, phase, and QSM images. Imaging of 20 consecutive MS patients was also reviewed for this Institutional Review Board (IRB)-approved MRI study to identify the appearance of solid and shell lesions on phase and QSM images. RESULTS: Solid and shell susceptibility sources were correctly reconstructed in QSM images, while the corresponding phase images depicted both geometries with shell-like patterns, making the underlying susceptibility distribution difficult to determine using phase alone. In MS patients, of the 60 largest lesions identified on T2 , 30 lesions were detected on both QSM and phase, of which 83% were solid and 17% were shells on QSM, and of which 30% were solid and 70% were shell on phase. Of the 21 shell-like lesions on phase, 76% appeared solid on QSM, 24% appeared shell on QSM. Of the five shell-like lesions on QSM, all were shell-like on phase. CONCLUSION: QSM accurately depicts both solid and shell patterns of magnetic susceptibility, while phase imaging fails to distinguish them.

publication date

  • August 30, 2014

Research

keywords

  • Brain
  • Diffusion Tensor Imaging
  • Image Interpretation, Computer-Assisted
  • Imaging, Three-Dimensional
  • Multiple Sclerosis
  • White Matter

Identity

PubMed Central ID

  • PMC4733654

Scopus Document Identifier

  • 84931837123

Digital Object Identifier (DOI)

  • 10.1002/cmr.b.10083

PubMed ID

  • 25174493

Additional Document Info

volume

  • 42

issue

  • 1