Gauthier, Susan A.

Publications

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selected publications

Larger lesion volume in people with multiple sclerosis is associated with increased transition energies between brain states and decreased entropy of brain activity. Network neuroscience (Cambridge, Mass.). 2023 Academic Article GET IT
Times cited: 42
Association of brain tissue cerebrospinal fluid fraction with age in healthy cognitively normal adults. Frontiers in aging neuroscience. 2023 Academic Article GET IT
Times cited: 5392
Evaluation of the Statistical Detection of Change Algorithm for Screening Patients with MS with New Lesion Activity on Longitudinal Brain MRI. AJNR. American journal of neuroradiology. 2023 Academic Article GET IT
Times cited: 12
Epsilon toxin-producing Clostridium perfringens colonize the multiple sclerosis gut microbiome overcoming CNS immune privilege. The Journal of clinical investigation. 2023 Academic Article GET IT
Times cited: 2
The sequence of regional structural disconnectivity due to multiple sclerosis lesions. bioRxiv : the preprint server for biology. 2023 Article GET IT
Times cited: 11
Location, location, location: myelin repair and proximity to ventricular CSF in multiple sclerosis. Brain : a journal of neurology. 2023 Editorial Article GET IT
Times cited: 2
Editorial: Measuring progression in Multiple Sclerosis: Progressing beyond the ordinary. Frontiers in human neuroscience. 2022 Editorial Article GET IT
Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer's disease progression and heterogeneity. Science advances. 2022 Academic Article GET IT
Times cited: 2
Toward Precision Phenotyping of Multiple Sclerosis. Neurology(R) neuroimmunology & neuroinflammation. 2022 Review GET IT
Times cited: 6
The CELLO trial: Protocol of a planned phase 4 study to assess the efficacy of Ocrelizumab in patients with radiologically isolated syndrome. Multiple sclerosis and related disorders. 2022 Academic Article GET IT
Times cited: 2
Magnetic Susceptibility Source Separation Solely from Gradient Echo Data: Histological Validation. Tomography (Ann Arbor, Mich.). 2022 Academic Article GET IT
Times cited: 2
Susceptibility source separation from gradient echo data using magnitude decay modeling. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2022 Academic Article GET IT
Times cited: 3
Disease correlates of rim lesions on quantitative susceptibility mapping in multiple sclerosis. Scientific reports. 2022 Academic Article GET IT
Times cited: 8
Quantitative susceptibility mapping versus phase imaging to identify multiple sclerosis iron rim lesions with demyelination. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2022 Academic Article GET IT
Times cited: 7
QSMRim-Net: Imbalance-aware learning for identification of chronic active multiple sclerosis lesions on quantitative susceptibility maps. NeuroImage. Clinical. 2022 Academic Article GET IT
Times cited: 8
Subsecond accurate myelin water fraction reconstruction from FAST-T₂ data with 3D UNET. Magnetic resonance in medicine. 2022 Academic Article GET IT
Times cited: 1
Dimethyl Fumarate Reduces Inflammation in Chronic Active Multiple Sclerosis Lesions. Neurology(R) neuroimmunology & neuroinflammation. 2022 Academic Article GET IT
Times cited: 12
Dynamic Functional Connectivity Better Predicts Disability Than Structural and Static Functional Connectivity in People With Multiple Sclerosis. Frontiers in neuroscience. 2021 Academic Article GET IT
Times cited: 47
The central vein sign in multiple sclerosis lesions: Susceptibility relaxation optimization from a routine MRI multiecho gradient echo sequence. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2021 Academic Article GET IT
ALL-Net: Anatomical information lesion-wise loss function integrated into neural network for multiple sclerosis lesion segmentation. NeuroImage. Clinical. 2021 Academic Article GET IT
Times cited: 4
Estimated connectivity networks outperform observed connectivity networks when classifying people with multiple sclerosis into disability groups. NeuroImage. Clinical. 2021 Academic Article GET IT
Times cited: 3
Brain oxygen extraction fraction mapping in patients with multiple sclerosis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 Academic Article GET IT
Times cited: 6
Structural disconnectivity from paramagnetic rim lesions is related to disability in multiple sclerosis. Brain and behavior. 2021 Academic Article GET IT
Times cited: 6
Global cerebrospinal fluid as a zero-reference regularization for brain quantitative susceptibility mapping. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2021 Academic Article GET IT
Times cited: 3
Lesion features on magnetic resonance imaging discriminate multiple sclerosis patients. European journal of neurology. 2021 Academic Article GET IT
Times cited: 1
Deep grey matter injury in multiple sclerosis: a NAIMS consensus statement. Brain : a journal of neurology. 2021 Conference Paper GET IT
Times cited: 17
Longitudinal change in TSPO PET imaging in progressive multiple sclerosis. Annals of clinical and translational neurology. 2021 Academic Article GET IT
Times cited: 5
Population-based input function for TSPO quantification and kinetic modeling with [¹¹C]-DPA-713. EJNMMI physics. 2021 Academic Article GET IT
Times cited: 35
QSM is an imaging biomarker for chronic glial activation in multiple sclerosis lesions. Annals of clinical and translational neurology. 2021 Academic Article GET IT
Times cited: 18
A Multi-Ligand Imaging Study Exploring GABAergic Receptor Expression and Inflammation in Multiple Sclerosis. Molecular imaging and biology. 2020 Academic Article GET IT
Times cited: 4
Estimation of Multiple Sclerosis lesion age on magnetic resonance imaging. NeuroImage. 2020 Academic Article GET IT
Times cited: 4
Impact of Lesion Location on Longitudinal Myelin Water Fraction Change in Chronic Multiple Sclerosis Lesions. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2020 Academic Article GET IT
Times cited: 5
Imaging Mechanisms of Disease Progression in Multiple Sclerosis: Beyond Brain Atrophy. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2020 Review GET IT
Times cited: 18
Black African and Latino/a identity correlates with increased plasmablasts in MS. Neurology(R) neuroimmunology & neuroinflammation. 2019 Academic Article GET IT
Times cited: 6
Quantitative Susceptibility Mapping of Time-Dependent Susceptibility Changes in Multiple Sclerosis Lesions. AJNR. American journal of neuroradiology. 2019 Academic Article GET IT
Times cited: 35
PET is necessary to make the next step forward in understanding MS pathophysiology - Commentary. Multiple sclerosis (Houndmills, Basingstoke, England). 2019 Comment GET IT
Times cited: 1
Imaging outcome measures of neuroprotection and repair in MS: A consensus statement from NAIMS. Neurology. 2019 Conference Paper GET IT
Times cited: 44
Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions. Brain : a journal of neurology. 2019 Academic Article GET IT
Times cited: 95
Comparison of two different methods of image analysis for the assessment of microglial activation in patients with multiple sclerosis using (R)-[N-methyl-carbon-11]PK11195. PloS one. 2018 Academic Article GET IT
Times cited: 7
Baseline biomarkers of connectome disruption and atrophy predict future processing speed in early multiple sclerosis. NeuroImage. Clinical. 2018 Academic Article GET IT
Times cited: 19
Noninvasive PK11195-PET Image Analysis Techniques Can Detect Abnormal Cerebral Microglial Activation in Parkinson's Disease. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2018 Academic Article GET IT
Times cited: 22
Induction of disease remission with one cycle of alemtuzumab in relapsing-remitting MS. Journal of neurology. 2018 Academic Article GET IT
Times cited: 1
Fast and Robust Unsupervised Identification of MS Lesion Change Using the Statistical Detection of Changes Algorithm. AJNR. American journal of neuroradiology. 2018 Academic Article GET IT
Times cited: 2
Magnetic susceptibility increases as diamagnetic molecules breakdown: Myelin digestion during multiple sclerosis lesion formation contributes to increase on QSM. Journal of magnetic resonance imaging : JMRI. 2018 Academic Article GET IT
Times cited: 25
Diagnostic accuracy of semiautomatic lesion detection plus quantitative susceptibility mapping in the identification of new and enhancing multiple sclerosis lesions. NeuroImage. Clinical. 2018 Academic Article GET IT
Times cited: 12
Quantitative Susceptibility Mapping of the Thalamus: Relationships with Thalamic Volume, Total Gray Matter Volume, and T2 Lesion Burden. AJNR. American journal of neuroradiology. 2018 Academic Article GET IT
Combining Quantitative Susceptibility Mapping with Automatic Zero Reference (QSM0) and Myelin Water Fraction Imaging to Quantify Iron-Related Myelin Damage in Chronic Active MS Lesions. AJNR. American journal of neuroradiology. 2017 Academic Article GET IT
Times cited: 27
Quantifying the Susceptibility Variation of Normal-Appearing White Matter in Multiple Sclerosis by Quantitative Susceptibility Mapping. AJR. American journal of roentgenology. 2017 Academic Article GET IT
Times cited: 11
MRI Analysis of White Matter Myelin Water Content in Multiple Sclerosis: A Novel Approach Applied to Finding Correlates of Cortical Thinning. Frontiers in neuroscience. 2017 Academic Article GET IT
Times cited: 4851
MRI in the assessment and monitoring of multiple sclerosis: an update on best practice. Therapeutic advances in neurological disorders. 2017 Review GET IT
Times cited: 58
Defining Disease Activity and Response to Therapy in MS. Current treatment options in neurology. 2017 Review GET IT
Times cited: 17
Reduction of PK11195 uptake observed in multiple sclerosis lesions after natalizumab initiation. Multiple sclerosis and related disorders. 2017 Academic Article GET IT
Times cited: 23
Clinical quantitative susceptibility mapping (QSM): Biometal imaging and its emerging roles in patient care. Journal of magnetic resonance imaging : JMRI. 2017 Review GET IT
Times cited: 160
Rapid whole brain myelin water content mapping without an external water standard at 1.5T. Magnetic resonance imaging. 2017 Academic Article GET IT
Times cited: 8
No evidence of disease activity in patients receiving daclizumab versus intramuscular interferon beta-1a for relapsing-remitting multiple sclerosis in the DECIDE study. Multiple sclerosis (Houndmills, Basingstoke, England). 2016 Academic Article GET IT
Times cited: 16
Differential Impact of Multiple Sclerosis on Cortical and Deep Gray Matter Structures in African Americans and Caucasian Americans. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2016 Academic Article GET IT
Times cited: 15
On the influence of zero-padding on the nonlinear operations in Quantitative Susceptibility Mapping. Magnetic resonance imaging. 2016 Academic Article GET IT
Times cited: 7
A study of patients with aggressive multiple sclerosis at disease onset. Neuropsychiatric disease and treatment. 2016 Academic Article GET IT
Times cited: 9
Magnetic Susceptibility from Quantitative Susceptibility Mapping Can Differentiate New Enhancing from Nonenhancing Multiple Sclerosis Lesions without Gadolinium Injection. AJNR. American journal of neuroradiology. 2016 Academic Article GET IT
Times cited: 200
Quantitative Susceptibility Mapping and R2* Measured Changes during White Matter Lesion Development in Multiple Sclerosis: Myelin Breakdown, Myelin Debris Degradation and Removal, and Iron Accumulation. AJNR. American journal of neuroradiology. 2016 Academic Article GET IT
Times cited: 48
Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM). Journal of magnetic resonance imaging : JMRI. 2016 Academic Article GET IT
Times cited: 64
Profilometry: A new statistical framework for the characterization of white matter pathways, with application to multiple sclerosis. Human brain mapping. 2015 Academic Article GET IT
Times cited: 23
Gadolinium-Enhancing Lesions Lead to Decreases in White Matter Tract Fractional Anisotropy in Multiple Sclerosis. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2015 Academic Article GET IT
Times cited: 9
Measuring longitudinal myelin water fraction in new multiple sclerosis lesions. NeuroImage. Clinical. 2015 Academic Article GET IT
Times cited: 46
Feasibility and reproducibility of whole brain myelin water mapping in 4 minutes using fast acquisition with spiral trajectory and adiabatic T2prep (FAST-T2) at 3T. Magnetic resonance in medicine. 2015 Academic Article GET IT
Times cited: 40
Reproducibility of quantitative susceptibility mapping in the brain at two field strengths from two vendors. Journal of magnetic resonance imaging : JMRI. 2015 Academic Article GET IT
Times cited: 78
Modeling the relationship among gray matter atrophy, abnormalities in connecting white matter, and cognitive performance in early multiple sclerosis. AJNR. American journal of neuroradiology. 2014 Academic Article GET IT
Times cited: 24
Multiple sclerosis lesion geometry in quantitative susceptibility mapping (QSM) and phase imaging. Journal of magnetic resonance imaging : JMRI. 2014 Academic Article GET IT
Times cited: 43
Quantitative susceptibility mapping (QSM) of white matter multiple sclerosis lesions: Interpreting positive susceptibility and the presence of iron. Magnetic resonance in medicine. 2014 Academic Article GET IT
Times cited: 167
Multi-compartment T2 relaxometry using a spatially constrained multi-Gaussian model. PloS one. 2014 Academic Article GET IT
Times cited: 39
Quantitative susceptibility mapping of multiple sclerosis lesions at various ages. Radiology. 2013 Academic Article GET IT
Times cited: 177
Robust myelin quantitative imaging from multi-echo T2 MRI using edge preserving spatial priors. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. 2013 Academic Article GET IT
Times cited: 5
Bayesian algorithm using spatial priors for multiexponential T₂ relaxometry from multiecho spin echo MRI. Magnetic resonance in medicine. 2012 Academic Article GET IT
Times cited: 49
T2 prep three-dimensional spiral imaging with efficient whole brain coverage for myelin water quantification at 1.5 tesla. Magnetic resonance in medicine. 2012 Academic Article GET IT
Times cited: 56
Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: a longitudinal study. Journal of the neurological sciences. 2011 Academic Article GET IT
Times cited: 13
Retinal nerve fiber layer evaluation in multiple sclerosis with spectral domain optical coherence tomography. Clinical ophthalmology (Auckland, N.Z.). 2010 Academic Article GET IT
Times cited: 46
HLA B*44: protective effects in MS susceptibility and MRI outcome measures. Neurology. 2010 Academic Article GET IT
Times cited: 67
Evaluating retinal abnormalities in patients with multiple sclerosis. Archives of neurology. 2010 Academic Article GET IT
Incidence and factors associated with treatment failure in the CLIMB multiple sclerosis cohort study. Journal of the neurological sciences. 2009 Academic Article GET IT
Times cited: 23
Rate of brain atrophy in benign vs early multiple sclerosis. Archives of neurology. 2009 Academic Article GET IT
Times cited: 39
Counseling for driving restrictions in epilepsy and other causes of temporary impairment of consciousness: how are we doing?. Epilepsy & behavior : E&B. 2009 Academic Article GET IT
Times cited: 22
Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale. Archives of neurology. 2008 Academic Article GET IT
Times cited: 46
Alcoholism leads to early perceptive alterations, independently of comorbid depressed state: an ERP study. Neurophysiologie clinique = Clinical neurophysiology. 2008 Academic Article GET IT
Times cited: 46
Estimating Time to Event From Longitudinal Categorical Data: An Analysis of Multiple Sclerosis Progression. Journal of the American Statistical Association. 2007 Academic Article GET IT
Times cited: 16
Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England). 2007 Academic Article GET IT
Times cited: 153
Predicting short-term disability in multiple sclerosis. Neurology. 2007 Academic Article GET IT
Times cited: 44
A model for the comprehensive investigation of a chronic autoimmune disease: the multiple sclerosis CLIMB study. Autoimmunity reviews. 2006 Review GET IT
Times cited: 114
Cyclophosphamide therapy for MS. International MS journal. 2005 Academic Article GET IT
Times cited: 10
Immunosuppressive therapy for multiple sclerosis. Neurologic clinics. 2005 Review GET IT
Times cited: 7
Methylprednisolone concentrations in the vitreous and the serum after pulse therapy. Retina (Philadelphia, Pa.). 2001 Academic Article GET IT
Times cited: 19
Fluctuations in tremor at rest and saccadic eye movements in subjects with Parkinsons disease. Parkinsonism & related disorders. 1997 Academic Article GET IT
Times cited: 9
Sleep and quantitative EEG in patients with progressive supranuclear palsy. Neurology. 1997 Academic Article GET IT
Times cited: 91

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Research

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Funding awarded

Establishing the clinical relevance of chronic active MS lesions and quantification of their inflammatory trajectory for a new treatment target awarded by National Multiple Sclerosis Society Principal Investigator 2022 - 2025
Examination of extracellular vesicles in patients with chronic active MS lesions awarded by Myelin Repair Foundation Principal Investigator 2019 - 2023
Identifying mechanisms of tissue injury in MS lesions: a multi-modality imaging approach awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2018 - 2023

Multi-modal neuroimaging and cognitive assessment of females with multiple sclerosis across different stages of menopause awarded by National Multiple Sclerosis Society Co-Investigator 2023 - 2028
Harboring the Initial Trigger of Multiple Sclerosis awarded by National Multiple Sclerosis Society Co-Investigator 2023 - 2026
Quantitative MRI of Lesion Iron and Myelin Repair awarded by National Multiple Sclerosis Society Co-Investigator 2016 - 2023

New PET/CT System for Human and Non-human Primate Imaging awarded by National Institutes of Health, Office of the Director Key Personnel 2023 - 2024
Major Cyclotron Upgrades and Refurbishment awarded by National Institutes of Health, Office of the Director Key Personnel 2021 - 2023
No-Gd MRI for Monitoring Disease Status in Multiple Sclerosis awarded by National Institute of Neurological Disorders & Stroke Key Personnel 2018 - 2023

Clinical Research Sites for the Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT sites) awarded by National Institute of Environmental Health Sciences Principal Investigator Subaward 2018 - 2023

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Background

education and training

M.P.H., Harvard School of Public Health 2005
D.O., Philadelphia College of Osteopathic Medicine 1997
B.S., State University of New York at Buffalo 1992

Contact

full name

Susan A. Gauthier

primary email

sag2015@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Susan A. Gauthier Associate Professor of Clinical Neurology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage