An expanding universe of mRNA modifications. Academic Article uri icon

Overview

abstract

  • The fate of mRNA can be regulated by internal base modifications, with the currently known modified bases being N6-methyladenosine, 5-methylcytosine, and inosine. Three new studies show that yeast and human mRNA also contain pseudouridine residues and that pseudouridylation is induced in various stress states, hinting at a new pathway for post-transcriptional control of mRNA.

publication date

  • November 1, 2014

Research

keywords

  • Pseudouridine
  • RNA Processing, Post-Transcriptional
  • RNA, Messenger
  • Saccharomyces cerevisiae

Identity

PubMed Central ID

  • PMC4384663

Scopus Document Identifier

  • 84908869950

Digital Object Identifier (DOI)

  • 10.1038/nsmb.2911

PubMed ID

  • 25372308

Additional Document Info

volume

  • 21

issue

  • 11