The effects of acute-phase inducers and dimethyl sulphoxide on delta-aminolaevulinate synthase activity in human HepG2 hepatoma cells. Academic Article uri icon

Overview

abstract

  • The effects of acute-phase inducers and dimethyl sulphoxide (Me2SO) on delta-aminolaevulinate (ALA) synthase in HepG2 cells were examined. Treatment of cells with Me2SO resulted in a significant increase in ALA synthase activity. Interleukin-6 increased ALA synthase activity only slightly, but it substantially potentiated the induction of ALA synthase by Me2SO. These data suggest that ALA synthase activity in liver is altered during acute-phase reactions.

publication date

  • April 15, 1989

Research

keywords

  • 5-Aminolevulinate Synthetase
  • Biological Factors
  • Carcinoma, Hepatocellular
  • Dimethyl Sulfoxide
  • Liver Neoplasms

Identity

PubMed Central ID

  • PMC1138553

Scopus Document Identifier

  • 0024516102

Digital Object Identifier (DOI)

  • 10.1042/bj2590605

PubMed ID

  • 2541694

Additional Document Info

volume

  • 259

issue

  • 2