Dangerous leaks: blood-brain barrier woes in the aging hippocampus. uri icon

Overview

abstract

  • A leaky blood-brain barrier has long been implicated in cognitive dysfunction in aging and neurodegeneration, but reliable human data were lacking. Here, Montagne et al. (2015) provide the first in vivo evidence of blood-brain barrier disruption in the aging hippocampus and in minimal cognitive impairment.

publication date

  • January 21, 2015

Research

keywords

  • Aging
  • Blood-Brain Barrier
  • CA1 Region, Hippocampal
  • CA3 Region, Hippocampal
  • Cognitive Dysfunction
  • Dentate Gyrus

Identity

PubMed Central ID

  • PMC4731877

Scopus Document Identifier

  • 84921405373

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2014.12.056

PubMed ID

  • 25611503

Additional Document Info

volume

  • 85

issue

  • 2