Integration of whole-genome sequencing into infection control practices: the potential and the hurdles. uri icon

Overview

abstract

  • Microbial whole-genome sequencing (WGS) is poised to transform many of the currently used approaches in medical microbiology. Recent reports on the application of WGS to understand genetic evolution and reconstruct transmission pathways have provided valuable information that will influence infection control practices. While this technology holds great promise, obstacles to full implementation remain. Two articles in this issue of the Journal of Clinical Microbiology (S. Octavia, Q. Wang, M. M. Tanaka, S. Kaur, V. Sintchenko, and R. Lan, J Clin Microbiol 53:1063-1071, 2015, doi:10.1128/JCM.03235-14, and S. J. Salipante, D. J. SenGupta, L. A. Cummings, T. A. Land, D. R. Hoogestraat, and B. T. Cookson, J Clin Microbiol 53:1072-1079, 2015, doi:10.1128/JCM.03385-14) describe the breadth of application of WGS to the field of clinical epidemiology.

publication date

  • February 11, 2015

Research

keywords

  • Disease Outbreaks
  • Genome, Bacterial
  • Molecular Epidemiology
  • Molecular Typing
  • Salmonella Infections
  • Salmonella typhimurium
  • Sequence Analysis, DNA

Identity

PubMed Central ID

  • PMC4365213

Scopus Document Identifier

  • 84925245476

Digital Object Identifier (DOI)

  • 10.1038/nrg3624

PubMed ID

  • 25673795

Additional Document Info

volume

  • 53

issue

  • 4