Tuberculosis Drug Development: History and Evolution of the Mechanism-Based Paradigm. Review uri icon

Overview

abstract

  • Modern tuberculosis (TB) chemotherapy is widely viewed as a crowning triumph of anti-infectives research. However, only one new TB drug has entered clinical practice in the past 40 years while drug resistance threatens to further destabilize the pandemic. Here, we review a brief history of TB drug development, focusing on the evolution of mechanism(s)-of-action studies and key conceptual barriers to rational, mechanism-based drugs.

publication date

  • April 15, 2015

Research

keywords

  • Antitubercular Agents
  • Drug Design
  • Mycobacterium tuberculosis
  • Tuberculosis

Identity

PubMed Central ID

  • PMC4526730

Scopus Document Identifier

  • 84938690697

Digital Object Identifier (DOI)

  • 10.1101/cshperspect.a021147

PubMed ID

  • 25877396

Additional Document Info

volume

  • 5

issue

  • 8