Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells. Review uri icon

Overview

abstract

  • Interleukin-10 and Interleukin-12 are produced primarily by pathogen-activated antigen-presenting cells, particularly macrophages and dendritic cells. IL-10 and IL-12 play very important immunoregulatory roles in host defense and immune homeostasis. Being anti- and pro-inflammatory in nature, respectively, their functions are antagonistically opposing. A comprehensive and in-depth understanding of their immunological properties and signaling mechanisms will help develop better clinical intervention strategies in therapy for a wide range of human disorders. Here, we provide an update on some emerging concepts, controversies, unanswered questions, and opinions regarding the immune signaling of IL-10 and IL-12.

publication date

  • December 17, 2015

Identity

PubMed Central ID

  • PMC4754024

Scopus Document Identifier

  • 84954534981

Digital Object Identifier (DOI)

  • 10.4161/2162402X.2014.994446

PubMed ID

  • 26918147

Additional Document Info

volume

  • 4