Ma, Xiaojing

Publications

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selected publications

Structure of the human UBR5 E3 ubiquitin ligase. Structure (London, England : 1993). 2023 Academic Article GET IT
Times cited: 1
Dexmedetomidine attenuates myocardial ischemia-reperfusion injury via inhibiting ferroptosis by the cAMP/PKA/CREB pathway. Molecular and cellular probes. 2023 Academic Article GET IT
Aberrant expression of GOLM1 protects ALK+ anaplastic large cell lymphoma from apoptosis by enhancing BCL-XL stability. Blood advances. 2023 Academic Article GET IT
UBR5 promotes tumor immune evasion through enhancing IFN-γ-induced PDL1 transcription in triple negative breast cancer. Theranostics. 2022 Academic Article GET IT
Times cited: 4
UBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer. Cell death & disease. 2022 Academic Article GET IT
Times cited: 2
RHAMM^B-mediated bifunctional nanotherapy targeting Bcl-xL and mitochondria for pancreatic neuroendocrine tumor treatment. Molecular therapy oncolytics. 2021 Academic Article GET IT
Times cited: 3
Functional Genomic Analysis of Breast Cancer Metastasis: Implications for Diagnosis and Therapy. Cancers. 2021 Review GET IT
Times cited: 86
Fascin inhibitor increases intratumoral dendritic cell activation and anti-cancer immunity. Cell reports. 2021 Academic Article GET IT
Times cited: 11
Combining UBR5 and CD163⁺ tumor-associated macrophages better predicts prognosis of clear cell renal cell carcinoma patients. Cancer immunology, immunotherapy : CII. 2021 Academic Article GET IT
Times cited: 3
Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages. Nature communications. 2020 Academic Article GET IT
Times cited: 47
Capping protein regulator and myosin 1 linker 3 regulates transcription of key cytokines in activated phagocytic cells. Cellular signalling. 2020 Academic Article GET IT
Times cited: 1
Structure-Activity Relationships of Noncovalent Immunoproteasome β5i-Selective Dipeptides. Journal of medicinal chemistry. 2020 Academic Article GET IT
Times cited: 9
Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response. Oncoimmunology. 2020 Academic Article GET IT
Times cited: 11
Immunoproteasome inhibitor DPLG3 attenuates experimental colitis by restraining NF-κB activation. Biochemical pharmacology. 2020 Academic Article GET IT
Times cited: 8
The omentum, a niche for premetastatic ovarian cancer. The Journal of experimental medicine. 2020 Comment GET IT
Times cited: 9
Correction: Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling. PLoS pathogens. 2020 Article GET IT
Isolation and Stimulation of Peritoneal Macrophages withApoptotic Jurkat Cells to Produce IL-10. Bio-protocol. 2019 Academic Article GET IT
Times cited: 1
Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications. Frontiers in oncology. 2019 Academic Article GET IT
Times cited: 286
Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis. Molecular cancer research : MCR. 2019 Academic Article GET IT
Times cited: 3
Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling. PLoS pathogens. 2019 Academic Article GET IT
Times cited: 23
Progranulin promotes melanoma progression by inhibiting natural killer cell recruitment to the tumor microenvironment. Cancer letters. 2019 Academic Article GET IT
Times cited: 16
Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Frontiers in immunology. 2019 Academic Article GET IT
Times cited: 2
Gankyrin is a novel biomarker for disease progression and prognosis of patients with renal cell carcinoma. EBioMedicine. 2018 Academic Article GET IT
Times cited: 13
Sensing danger through a "finger". The Journal of experimental medicine. 2018 Comment GET IT
Times cited: 1
Targeting an Autocrine Regulatory Loop in Cancer Stem-like Cells Impairs the Progression and Chemotherapy Resistance of Bladder Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 Academic Article GET IT
Times cited: 27
Recent advances in understanding dendritic cell development, classification, and phenotype. F1000Research. 2018 Review GET IT
Times cited: 17
Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo. Nature biotechnology. 2018 Academic Article GET IT
Times cited: 446
DNA Thioaptamer with Homing Specificity to Lymphoma Bone Marrow Involvement. Molecular pharmaceutics. 2018 Academic Article GET IT
Times cited: 10
Golgi Phosphoprotein 2 Is a Novel Regulator of IL-12 Production and Macrophage Polarization. Journal of immunology (Baltimore, Md. : 1950). 2018 Academic Article GET IT
Times cited: 8
Subunit Vaccines Consisting of Antigens from Dormant and Replicating Bacteria Show Promising Therapeutic Effect against Mycobacterium Bovis BCG Latent Infection. Scandinavian journal of immunology. 2017 Academic Article GET IT
Times cited: 11
Targeting Autocrine CCL5-CCR5 Axis Reprograms Immunosuppressive Myeloid Cells and Reinvigorates Antitumor Immunity. Cancer research. 2017 Academic Article GET IT
Times cited: 90
E3 Ubiquitin Ligase UBR5 Drives the Growth and Metastasis of Triple-Negative Breast Cancer. Cancer research. 2017 Academic Article GET IT
Times cited: 63
Synthesis and biological activities of C-glycosides of KRN 7000 with novel ceramide residues. Carbohydrate research. 2017 Academic Article GET IT
Times cited: 10
An Infectious Disease-Associated Il12b Polymorphism Regulates IL-12/23 p40 Transcription Involving Poly(ADP-Ribose) Polymerase 1. Journal of immunology (Baltimore, Md. : 1950). 2017 Academic Article GET IT
Times cited: 5
Gamma Interferon-Regulated Chemokines in Leishmania donovani Infection in the Liver. Infection and immunity. 2016 Academic Article GET IT
Times cited: 15
Progranulin Controls Sepsis via C/EBPα-Regulated Il10 Transcription and Ubiquitin Ligase/Proteasome-Mediated Protein Degradation. Journal of immunology (Baltimore, Md. : 1950). 2016 Academic Article GET IT
Times cited: 18
Establishing estrogen-responsive mouse mammary organoids from single Lgr5⁺ cells. Cellular signalling. 2016 Academic Article GET IT
Times cited: 30
Regulation of Interleukin-12 Production in Antigen-Presenting Cells. Advances in experimental medicine and biology. 2016 Review GET IT
Times cited: 26
Regulation of Interleukin-17 Production. Advances in experimental medicine and biology. 2016 Review GET IT
Times cited: 3
The Immunobiology of Interleukin-35 and Its Regulation and Gene Expression. Advances in experimental medicine and biology. 2016 Review GET IT
Times cited: 28
Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells. F1000Research. 2015 Review GET IT
Times cited: 281
IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver. Experimental parasitology. 2015 Academic Article GET IT
Times cited: 8
A novel crosstalk between TLR4- and NOD2-mediated signaling in the regulation of intestinal inflammation. Scientific reports. 2015 Academic Article GET IT
Times cited: 28
Synthesis and biological evaluation of kojic acid derivatives containing 1,2,4-triazole as potent tyrosinase inhibitors. Chemical biology & drug design. 2015 Academic Article GET IT
Times cited: 27
Recent Advances in Discovering the Role of CCL5 in Metastatic Breast Cancer. Mini reviews in medicinal chemistry. 2015 Review GET IT
Times cited: 46
Granzyme-mediated regulation of host defense in the liver in experimental Leishmania donovani infection. Infection and immunity. 2014 Academic Article GET IT
Times cited: 2
Regulatory actions of Toll-like receptor 2 (TLR2) and TLR4 in Leishmania donovani infection in the liver. Infection and immunity. 2013 Academic Article GET IT
Times cited: 35
CCL5 as a potential immunotherapeutic target in triple-negative breast cancer. Cellular & molecular immunology. 2013 Review GET IT
Times cited: 69
A novel role of hematopoietic CCL5 in promoting triple-negative mammary tumor progression by regulating generation of myeloid-derived suppressor cells. Cell research. 2012 Academic Article GET IT
Times cited: 97
Type I interferon: the mediator of bacterial infection-induced necroptosis. Cellular & molecular immunology. 2012 Review GET IT
Times cited: 10
Golgi phosphoprotein 2 in physiology and in diseases. Cell & bioscience. 2012 Academic Article GET IT
Times cited: 106
IL-17, a new kid on the block of tertiary lymphoid organs. Cellular & molecular immunology. 2011 Comment GET IT
Times cited: 2
Large-vessel granulomatous vasculitis in Crohn's disease: a clinical pathology conference held by the division of rheumatology at hospital for special surgery. HSS journal : the musculoskeletal journal of Hospital for Special Surgery. 2010 Academic Article GET IT
Times cited: 40
Regulation of interleukin-10 gene expression in macrophages engulfing apoptotic cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2010 Review GET IT
Times cited: 30
Triptolide inhibits IL-12/IL-23 expression in APCs via CCAAT/enhancer-binding protein alpha. Journal of immunology (Baltimore, Md. : 1950). 2010 Academic Article GET IT
Times cited: 38
The septic shock-associated IL-10 -1082 A > G polymorphism mediates allele-specific transcription via poly(ADP-Ribose) polymerase 1 in macrophages engulfing apoptotic cells. Journal of immunology (Baltimore, Md. : 1950). 2010 Academic Article GET IT
Times cited: 35
c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 107
Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. The Journal of experimental medicine. 2009 Academic Article GET IT
Times cited: 355
Role of Nod2 in the development of Crohn's disease. Microbes and infection. 2009 Review GET IT
Times cited: 50
SUMO conjugation contributes to immune deviation in nonobese diabetic mice by suppressing c-Maf transactivation of IL-4. Journal of immunology (Baltimore, Md. : 1950). 2009 Academic Article GET IT
Times cited: 20
A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1. Nature immunology. 2009 Academic Article GET IT
Times cited: 161
Transcriptional inhibition of interleukin-12 promoter activity in Leishmania spp.-infected macrophages. The Journal of parasitology. 2008 Academic Article GET IT
Times cited: 17
Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1. Immunity. 2007 Academic Article GET IT
Times cited: 184
Nod1 and Nod2 induce CCL5/RANTES through the NF-kappaB pathway. European journal of immunology. 2007 Academic Article GET IT
Times cited: 69
The Th2 transcription factor c-Maf inhibits IL-12p35 gene expression in activated macrophages by targeting NF-kappaB nuclear translocation. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2007 Academic Article GET IT
Times cited: 25
Differential expression in lupus-associated IL-10 promoter single-nucleotide polymorphisms is mediated by poly(ADP-ribose) polymerase-1. Genes and immunity. 2007 Academic Article GET IT
Times cited: 32
Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-gamma-mediated pathways. The Journal of experimental medicine. 2007 Academic Article GET IT
Times cited: 149
FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin. Immunity. 2007 Academic Article GET IT
Times cited: 137
The circadian clock Period 2 gene regulates gamma interferon production of NK cells in host response to lipopolysaccharide-induced endotoxic shock. Infection and immunity. 2006 Academic Article GET IT
Times cited: 182
Responses to Leishmania donovani in mice deficient in interleukin-12 (IL-12), IL-12/IL-23, or IL-18. Infection and immunity. 2006 Academic Article GET IT
Times cited: 39
Responses to Leishmania donovani in mice deficient in both phagocyte oxidase and inducible nitric oxide synthase. The American journal of tropical medicine and hygiene. 2006 Academic Article GET IT
Times cited: 30
Interferon regulatory factor 8 regulates RANTES gene transcription in cooperation with interferon regulatory factor-1, NF-kappaB, and PU.1. The Journal of biological chemistry. 2006 Academic Article GET IT
Times cited: 44
Visceral Leishmania donovani infection in interleukin-13-/- mice. Infection and immunity. 2006 Academic Article GET IT
Times cited: 19
An adenoviral vector for probing promoter activity in primary immune cells. Journal of immunological methods. 2006 Academic Article GET IT
Times cited: 2
Regulation of cytokine production during phagocytosis of apoptotic cells. Cell research. 2006 Review GET IT
Times cited: 80
Diminished expression of transcription factors nuclear factor kappaB and CCAAT/enhancer binding protein underlies a novel tumor evasion mechanism affecting macrophages of mammary tumor-bearing mice. Cancer research. 2005 Academic Article GET IT
Times cited: 38
Obesity-related glomerulopathy: insights from gene expression profiles of the glomeruli derived from renal biopsy samples. Endocrinology. 2005 Academic Article GET IT
Times cited: 132
Antagonizing deactivating cytokines to enhance host defense and chemotherapy in experimental visceral leishmaniasis. Infection and immunity. 2005 Academic Article GET IT
Times cited: 60
Interleukin-12: an update on its immunological activities, signaling and regulation of gene expression. Current immunology reviews. 2005 Academic Article GET IT
Interferon regulatory factor 1 is an essential and direct transcriptional activator for interferon {gamma}-induced RANTES/CCl5 expression in macrophages. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 66
The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages. Journal of immunology (Baltimore, Md. : 1950). 2005 Academic Article GET IT
Times cited: 188
Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 150
Immunological consequences of macrophage-mediated clearance of apoptotic cells. Cell cycle (Georgetown, Tex.). 2005 Academic Article GET IT
Times cited: 15
Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cells. Immunity. 2004 Academic Article GET IT
Times cited: 239
Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 93
Global gene expression profiling in interleukin-12-induced activation of CD8(+) cytotoxic T lymphocytes against mouse mammary Carcinoma. Cellular & molecular immunology. 2004 Academic Article GET IT
Times cited: 6
Role of IFN regulatory factor-1 and IL-12 in immunological resistance to pathogenesis of N-methyl-N-nitrosourea-induced T lymphoma. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 27
Gene expression analysis in Interleukin-12-induced suppression of mouse mammary carcinoma. International journal of cancer. 2004 Academic Article GET IT
Times cited: 17
Regulation of interleukin-12 gene expression and its anti-tumor activities by prostaglandin E2 derived from mammary carcinomas. Journal of leukocyte biology. 2004 Review GET IT
Times cited: 41
Genome-wide analysis of molecular changes in IL-12-induced control of mammary carcinoma via IFN-gamma-independent mechanisms. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 26
Activation and repression of interleukin-12 p40 transcription by erythroid Kruppel-like factor in macrophages. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 45
Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1. The Journal of experimental medicine. 2003 Academic Article GET IT
Times cited: 159
Determinants of response to interleukin-10 receptor blockade immunotherapy in experimental visceral leishmaniasis. The Journal of infectious diseases. 2003 Academic Article GET IT
Times cited: 81
Microarray expression profiling: analysis and applications. Current opinion in drug discovery & development. 2003 Review GET IT
Times cited: 41
Opsonization of apoptotic cells and its effect on macrophage and T cell immune responses. Annals of the New York Academy of Sciences. 2003 Review GET IT
Times cited: 70
Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma. Journal of immunology (Baltimore, Md. : 1950). 2002 Academic Article GET IT
Times cited: 98
I-PLA(2) activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation. The Journal of experimental medicine. 2002 Academic Article GET IT
Times cited: 236
Type I interferons and IL-12: convergence and cross-regulation among mediators of cellular immunity. European journal of immunology. 2001 Academic Article GET IT
Times cited: 77
Suppression of Il-12 transcription in macrophages following Fc gamma receptor ligation. Journal of immunology (Baltimore, Md. : 1950). 2001 Academic Article GET IT
Times cited: 86
TNF-alpha and IL-12: a balancing act in macrophage functioning. Microbes and infection. 2001 Review GET IT
Times cited: 109
Regulation of interleukin-12 production in antigen-presenting cells. Advances in immunology. 2001 Review GET IT
Times cited: 174
Proinflammatory response and IL-12 expression in HIV-1 infection. Journal of leukocyte biology. 2000 Review GET IT
Times cited: 52
An IFN-gamma-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages. Journal of immunology (Baltimore, Md. : 1950). 2000 Academic Article GET IT
Times cited: 160
Inhibition of IL-12 production in human monocyte-derived macrophages by TNF. Journal of immunology (Baltimore, Md. : 1950). 2000 Academic Article GET IT
Times cited: 89
Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFkappaB. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 220
Downregulation of interleukin-12 (IL-12) responsiveness in human T cells by transforming growth factor-beta: relationship with IL-12 signaling. Blood. 1999 Academic Article GET IT
Times cited: 54
Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance. European journal of immunology. 1998 Academic Article GET IT
Times cited: 120
Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10. Journal of immunology (Baltimore, Md. : 1950). 1998 Academic Article GET IT
Times cited: 325
Synergistic regulation of the human interleukin-12 p40 promoter by NFkappaB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 87
Inhibition of IL-12 production by thalidomide. Journal of immunology (Baltimore, Md. : 1950). 1997 Academic Article GET IT
Times cited: 220
Inhibition of human interleukin-12 production by pentoxifylline. Immunology. 1997 Academic Article GET IT
Times cited: 81
Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 129
Immunomodulatory functions and molecular regulation of IL-12. Chemical immunology. 1997 Review GET IT
Times cited: 53
Interleukin-12: an immunoregulatory cytokine produced by B cells and antigen-presenting cells. Methods (San Diego, Calif.). 1997 Academic Article GET IT
Times cited: 47
A novel ets-2-related nuclear factor is involved in transcriptional activation of the human interleukin-12 p40 gene promoter in response to interferon-gamma and LPS stimulation of monocytic cells. Annals of the New York Academy of Sciences. 1996 Academic Article GET IT
Times cited: 15
Regulation by interleukin-10 of Staphylococcus aureus- and lipopolysaccharide-induced interleukin-12 gene expression in human peripheral blood mononuclear cells. Annals of the New York Academy of Sciences. 1996 Academic Article GET IT
Times cited: 3
Regulation of interleukin-12 production. Annals of the New York Academy of Sciences. 1996 Review GET IT
Times cited: 33
Differential production of interleukin 10 during human immunodeficiency virus infection. AIDS research and human retroviruses. 1996 Academic Article GET IT
Times cited: 27
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. The Journal of experimental medicine. 1996 Academic Article GET IT
Times cited: 586
Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production. The Journal of experimental medicine. 1995 Academic Article GET IT
Times cited: 363
Interleukin-12 production by human polymorphonuclear leukocytes. European journal of immunology. 1995 Academic Article GET IT
Times cited: 274
Production of interleukin-12. Research in immunology. 1995 Review GET IT
Times cited: 40
Impaired interleukin 12 production in human immunodeficiency virus-infected patients. The Journal of experimental medicine. 1994 Academic Article GET IT
Times cited: 416
Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. The Journal of experimental medicine. 1993 Academic Article GET IT
Times cited: 1327
Purification and characterization of a nuclear DNA-binding factor complex containing topoisomerase II and chromosome scaffold protein 2. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 21
A differentiation stage-specific factor interacts with mouse carbonic anhydrase form I gene and a conserved sequence in mammalian beta-globin genes. Differentiation; research in biological diversity. 1991 Academic Article GET IT
Times cited: 2

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Research

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Funding awarded

UBR5''s Mechanisms of Action in Tumorigenesis and Immunoregulation awarded by National Cancer Institute Principal Investigator 2023 - 2028
Investigation of UBR5 and its signaling as a novel target for breast cancer therapy awarded by United States Department of Defense Principal Investigator 2021 - 2024

UBR5, E3 Ubiquitin Ligase, in Triple Negative Breast Cancers: Potential Role in Anti-Tumor Immunity and Cancer Metabolism awarded by Qatar Foundation Co-Investigator 2020 - 2024

UBR5, E3 Ubiquitin Ligase, in Triple Negative Breast Cancers: Potential Role in Anti-Tumor Immunity and Cancer Metabo awarded by Qatar National Research Fund Principal Investigator Subaward 2020 - 2024

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Background

education and training

Ph.D., Edinburgh University (Scotland) 1987
B.A., Beijing Agricultural University (China) 1982

Contact

full name

Xiaojing Ma

primary email

xim2002@med.cornell.edu

VIVO Weill Cornell Medical College

Xiaojing Ma Professor of Microbiology and Immunology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email