Hallmarks of Tissue-Resident Lymphocytes. Review uri icon

Overview

abstract

  • Although they are classically viewed as continuously recirculating through the lymphoid organs and blood, lymphocytes also establish residency in non-lymphoid tissues, most prominently at barrier sites, including the mucosal surfaces and skin. These specialized tissue-resident lymphocyte subsets span the innate-adaptive continuum and include innate lymphoid cells (ILCs), unconventional T cells (e.g., NKT, MAIT, γδ T cells, and CD8αα(+) IELs), and tissue-resident memory T (T(RM)) cells. Although these diverse cell types differ in the particulars of their biology, they nonetheless exhibit important shared features, including a role in the preservation of tissue integrity and function during homeostasis, infection, and non-infectious perturbations. In this Review, we discuss the hallmarks of tissue-resident innate, innate-like, and adaptive lymphocytes, as well as their potential functions in non-lymphoid organs.

publication date

  • March 10, 2016

Research

keywords

  • Lymphocytes

Identity

PubMed Central ID

  • PMC4973889

Scopus Document Identifier

  • 84960457526

Digital Object Identifier (DOI)

  • 10.1126/science.aaf1648

PubMed ID

  • 26967286

Additional Document Info

volume

  • 164

issue

  • 6