Targeting abnormal ER stress responses in tumors: A new approach to cancer immunotherapy. Academic Article uri icon

Overview

abstract

  • Cancers thrive under adverse conditions and simultaneously inhibit antitumor immunity. We recently found that endoplasmic reticulum (ER) stress responses driven by the IRE1α-XBP1 pathway not only promote cancer cell survival, but also provoke severe dendritic cell (DC) dysfunction in tumors. Targeting IRE1α-XBP1 represents a two-pronged approach to restrain malignant cells while eliciting concomitant antitumor immunity.

publication date

  • October 29, 2015

Identity

PubMed Central ID

  • PMC4839339

Scopus Document Identifier

  • 68849112640

Digital Object Identifier (DOI)

  • 10.1172/JCI37716

PubMed ID

  • 27141359

Additional Document Info

volume

  • 5

issue

  • 3