Cubillos-Ruiz, Juan R

Publications

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Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell death and differentiation. 2023 Review GET IT
Control of immune cell function by the unfolded protein response. Nature reviews. Immunology. 2023 Review GET IT
Times cited: 918
Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer. Nature communications. 2023 Academic Article GET IT
Times cited: 2
Remodeling of the Enterococcal Cell Envelope during Surface Penetration Promotes Intrinsic Resistance to Stress. mBio. 2022 Academic Article GET IT
Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses. Cancer cell. 2022 Academic Article GET IT
Times cited: 7
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses. The Journal of experimental medicine. 2022 Academic Article GET IT
Times cited: 4
Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer. Cancer discovery. 2022 Academic Article GET IT
Times cited: 9
Decoding endoplasmic reticulum stress signals in cancer cells and antitumor immunity. Trends in cancer. 2022 Review GET IT
Times cited: 8
High-Fat Diet-Induced Obesity Alters Dendritic Cell Homeostasis by Enhancing Mitochondrial Fatty Acid Oxidation. Journal of immunology (Baltimore, Md. : 1950). 2022 Academic Article GET IT
Times cited: 5
Fungal Patterns Induce Cytokine Expression through Fluxes of Metabolic Intermediates That Support Glycolysis and Oxidative Phosphorylation. Journal of immunology (Baltimore, Md. : 1950). 2022 Academic Article GET IT
Times cited: 2
Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer. Proceedings of the National Academy of Sciences of the United States of America. 2022 Academic Article GET IT
Times cited: 19
Methods and protocols for chemotherapy-induced peripheral neuropathy (CIPN) mouse models using paclitaxel. Methods in cell biology. 2022 Academic Article GET IT
Times cited: 1
Engineered bacteria recycle tumor metabolic waste to boost immunotherapy. Cell host & microbe. 2021 Academic Article GET IT
Times cited: 2
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α. The EMBO journal. 2021 Article GET IT
Optineurin Guards IFNγ Signaling in Cancer Cells. Cancer discovery. 2021 Comment GET IT
Times cited: 1
Endoplasmic reticulum stress signals in the tumour and its microenvironment. Nature reviews. Cancer. 2020 Review GET IT
Times cited: 296
Dietary Fructose Alters the Composition, Localization, and Metabolism of Gut Microbiota in Association With Worsening Colitis. Cellular and molecular gastroenterology and hepatology. 2020 Academic Article GET IT
Times cited: 43
BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells. Science (New York, N.Y.). 2020 Academic Article GET IT
Times cited: 55
The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling. Immunity. 2020 Academic Article GET IT
Times cited: 76
The impact of endoplasmic reticulum stress responses in dendritic cell immunobiology. International review of cell and molecular biology. 2019 Review GET IT
Times cited: 8
Publisher Correction: ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression. Nature communications. 2019 Article GET IT
Times cited: 3
IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain. Science (New York, N.Y.). 2019 Academic Article GET IT
Times cited: 60
Dendritic Cell Metabolism and Function in Tumors. Trends in immunology. 2019 Review GET IT
Times cited: 88
Somatic mutations and cell identity linked by Genotyping of Transcriptomes. Nature. 2019 Academic Article GET IT
Times cited: 129
Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns. Cell reports. 2019 Academic Article GET IT
Times cited: 17
ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression. Nature communications. 2019 Academic Article GET IT
Times cited: 63
PolyGlcNAc-containing exopolymers enable surface penetration by non-motile Enterococcus faecalis. PLoS pathogens. 2019 Academic Article GET IT
Times cited: 20
Endoplasmic Reticulum Stress Responses in Intratumoral Immune Cells: Implications for Cancer Immunotherapy. Trends in immunology. 2019 Review GET IT
Times cited: 44
IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity. Nature. 2018 Academic Article GET IT
Times cited: 205
Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nature cell biology. 2018 Academic Article GET IT
Times cited: 887
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell death and differentiation. 2018 Review GET IT
Times cited: 2998
Endoplasmic Reticulum Stress Sensor IRE1α Enhances IL-23 Expression by Human Dendritic Cells. Frontiers in immunology. 2017 Academic Article GET IT
Times cited: 314
Dendritic cell rehab: new strategies to unleash therapeutic immunity in ovarian cancer. Cancer immunology, immunotherapy : CII. 2017 Review GET IT
Times cited: 18
Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer. Cell. 2017 Review GET IT
Times cited: 496
Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer. Journal for immunotherapy of cancer. 2017 Review GET IT
Times cited: 62
State-of-the-art of regulatory dendritic cells in cancer. Pharmacology & therapeutics. 2016 Review GET IT
Times cited: 34
Molecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment. Clinical cancer research : an official journal of the American Association for Cancer Research. 2016 Review GET IT
Times cited: 26
Targeting abnormal ER stress responses in tumors: A new approach to cancer immunotherapy. Oncoimmunology. 2015 Academic Article GET IT
Times cited: 184
IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection. Nature communications. 2015 Academic Article GET IT
Times cited: 49
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis. Cell. 2015 Academic Article GET IT
Times cited: 512
Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment. Cancer research. 2013 Academic Article GET IT
Times cited: 70
Reprogramming immune responses via microRNA modulation. microRNA diagnostics and therapeutics. 2013 Academic Article GET IT
Times cited: 4
Good things come in small packages: Therapeutic anti-tumor immunity induced by microRNA nanoparticles. Oncoimmunology. 2012 Academic Article GET IT
Times cited: 1215
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α. The EMBO journal. 2012 Academic Article GET IT
Times cited: 95
Ovarian cancer progression is controlled by phenotypic changes in dendritic cells. The Journal of experimental medicine. 2012 Academic Article GET IT
Times cited: 242
Reprogramming tumor-associated dendritic cells in vivo using miRNA mimetics triggers protective immunity against ovarian cancer. Cancer research. 2012 Academic Article GET IT
Times cited: 131
It never rains but it pours: potential role of butyrophilins in inhibiting anti-tumor immune responses. Cell cycle (Georgetown, Tex.). 2011 Editorial Article GET IT
Times cited: 6
Effects of IFN-α as a signal-3 cytokine on human naïve and antigen-experienced CD8(+) T cells. European journal of immunology. 2010 Academic Article GET IT
Times cited: 55
Antifungal mechanisms by which a novel Pseudomonas aeruginosa phenazine toxin kills Candida albicans in biofilms. Molecular microbiology. 2010 Academic Article GET IT
Times cited: 109
CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells. Oncotarget. 2010 Academic Article GET IT
Times cited: 61
CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells. Journal of immunology (Baltimore, Md. : 1950). 2010 Academic Article GET IT
Times cited: 66
Blocking ovarian cancer progression by targeting tumor microenvironmental leukocytes. Cell cycle (Georgetown, Tex.). 2010 Review GET IT
Times cited: 33
Nanomolecular targeting of dendritic cells for ovarian cancer therapy. Future oncology (London, England). 2009 Editorial Article GET IT
Times cited: 16
In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells. Cancer research. 2009 Academic Article GET IT
Times cited: 113
CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion. Cancer research. 2009 Academic Article GET IT
Times cited: 46
Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity. The Journal of clinical investigation. 2009 Academic Article GET IT
Times cited: 185
Depletion of dendritic cells delays ovarian cancer progression by boosting antitumor immunity. Cancer research. 2008 Academic Article GET IT
Times cited: 96
PILAR is a novel modulator of human T-cell expansion. Blood. 2008 Academic Article GET IT
Times cited: 31
Effect of delayed graft function in hypersensitized kidney transplant recipients. Human immunology. 2005 Review GET IT
Times cited: 10

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Research

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Co-investigator Network

Funding awarded

Immunometabolic Programs Controlled by ER Stress in Cancer awarded by National Cancer Institute Principal Investigator 2023 - 2028
A sUPR driver of T cell metabolic dysfunction in ovarian cancer awarded by United States Department of Defense Principal Investigator 2023 - 2026
PERK-Driven Stress Responses Regulate Dendritic Cell Function in Ovarian Cancer awarded by United States Department of Defense Principal Investigator 2021 - 2024
Harnessing Dietary n-3 Fatty Acids to Unleash Protective Immunity Against Ovarian Cancer awarded by United States Department of Defense Principal Investigator 2021 - 2024
The Mark Foundation ASPIRE Phase II Proposal awarded by The Mark Foundation for Cancer Research Principal Investigator 2020 - 2023

ER stress-driven IRE1a-XBP1 signaling in lung cancer awarded by National Cancer Institute Key Personnel 2023 - 2028
Decoding ER stress signaling in ovarian cancer-reactive T cells awarded by American Association for Cancer Research Key Personnel 2022 - 2024
Immunosuppressive Programs Driven by IRE1 signaling in ovarian cancer awarded by National Cancer Institute Key Personnel 2021 - 2024

Regulation of T cell immune response in Heart Failure with Preserved Ejection Fraction awarded by National Heart, Lung, & Blood Institute Principal Investigator Subaward 2023 - 2027
Endoplasmic Reticulum Stress Responses in Pain awarded by National Institute of Neurological Disorders & Stroke Principal Investigator Subaward 2020 - 2025

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Background

education and training

Ph.D., Dartmouth Medical School 2010
B.S., University of the Andes (Colombia) 2004

Contact

full name

Juan R Cubillos-Ruiz

primary email

jur2016@med.cornell.edu

VIVO Weill Cornell Medical College

Juan R Cubillos-Ruiz Associate Professor of Microbiology and Immunology in Obstetrics and Gynecology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email