Sampling Hyperpolarized Molecules Utilizing a 1 Tesla Permanent Magnetic Field. Academic Article uri icon

Overview

abstract

  • Hyperpolarized magnetic resonance spectroscopy (HP MRS) using dynamic nuclear polarization (DNP) is a technique that has greatly enhanced the sensitivity of detecting (13)C nuclei. However, the HP MRS polarization decays in the liquid state according to the spin-lattice relaxation time (T1) of the nucleus. Sampling of the signal also destroys polarization, resulting in a limited temporal ability to observe biologically interesting reactions. In this study, we demonstrate that sampling hyperpolarized signals using a permanent magnet at 1 Tesla (1T) is a simple and cost-effective method to increase T1s without sacrificing signal-to-noise. Biologically-relevant information may be obtained with a permanent magnet using enzyme solutions and in whole cells. Of significance, our findings indicate that changes in pyruvate metabolism can also be quantified in a xenograft model at this field strength.

publication date

  • September 6, 2016

Research

keywords

  • Lactic Acid
  • Magnetic Fields
  • Prostatic Neoplasms
  • Pyruvic Acid
  • Sarcoma

Identity

PubMed Central ID

  • PMC5011774

Scopus Document Identifier

  • 84986571215

Digital Object Identifier (DOI)

  • 10.1002/Jmri.22484

PubMed ID

  • 27597137

Additional Document Info

volume

  • 6