Inflammation and Stroke: An Overview. Review uri icon

Overview

abstract

  • The immune response to acute cerebral ischemia is a major factor in stroke pathobiology and outcome. While the immune response starts locally in occluded and hypoperfused vessels and the ischemic brain parenchyma, inflammatory mediators generated in situ propagate through the organism as a whole. This "spillover" leads to a systemic inflammatory response first, followed by immunosuppression aimed at dampening the potentially harmful proinflammatory milieu. In this overview we will outline the inflammatory cascade from its starting point in the vasculature of the ischemic brain to the systemic immune response elicited by brain ischemia. Potential immunomodulatory therapeutic approaches, including preconditioning and immune cell therapy will also be discussed.

publication date

  • October 1, 2016

Research

keywords

  • Brain
  • Inflammation
  • Stroke

Identity

PubMed Central ID

  • PMC5081118

Scopus Document Identifier

  • 84991066526

Digital Object Identifier (DOI)

  • 10.1161/01.STR.0000141680.49960.d7

PubMed ID

  • 27730544

Additional Document Info

volume

  • 13

issue

  • 4