Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion. Academic Article uri icon

Overview

abstract

  • CD8+ T cell recognition of virus-infected cells is characteristically restricted by major histocompatibility complex (MHC) class I, although rare examples of MHC class II restriction have been reported in Cd4-deficient mice and a macaque SIV vaccine trial using a recombinant cytomegalovirus vector. Here, we demonstrate the presence of human leukocyte antigen (HLA) class II-restricted CD8+ T cell responses with antiviral properties in a small subset of HIV-infected individuals. In these individuals, T cell receptor β (TCRβ) analysis revealed that class II-restricted CD8+ T cells underwent clonal expansion and mediated killing of HIV-infected cells. In one case, these cells comprised 12% of circulating CD8+ T cells, and TCRα analysis revealed two distinct co-expressed TCRα chains, with only one contributing to binding of the class II HLA-peptide complex. These data indicate that class II-restricted CD8+ T cell responses can exist in a chronic human viral infection, and may contribute to immune control.

publication date

  • October 18, 2016

Research

keywords

  • Antiviral Agents
  • CD8-Positive T-Lymphocytes
  • HIV Infections
  • Histocompatibility Antigens Class II
  • Receptors, Antigen, T-Cell, alpha-beta

Identity

PubMed Central ID

  • PMC5077698

Scopus Document Identifier

  • 84994884814

Digital Object Identifier (DOI)

  • 10.1016/j.immuni.2016.09.015

PubMed ID

  • 27760342

Additional Document Info

volume

  • 45

issue

  • 4