The aryl hydrocarbon receptor controls cell-fate decisions in B cells. Academic Article uri icon

Overview

abstract

  • Generation of cellular heterogeneity is an essential feature of the adaptive immune system. This is best exemplified during humoral immune response when an expanding B cell clone assumes multiple cell fates, including class-switched B cells, antibody-secreting plasma cells, and memory B cells. Although each cell type is essential for immunity, their generation must be exquisitely controlled because a class-switched B cell cannot revert back to the parent isotype, and a terminally differentiated plasma cell cannot contribute to the memory pool. In this study, we show that an environmental sensor, the aryl hydrocarbon receptor (AhR) is highly induced upon B cell activation and serves a critical role in regulating activation-induced cell fate outcomes. We find that AhR negatively regulates class-switch recombination ex vivo by altering activation-induced cytidine deaminase expression. We further demonstrate that AhR suppresses class switching in vivo after influenza virus infection and immunization with model antigens. In addition, by regulating Blimp-1 expression via Bach2, AhR represses differentiation of B cells into plasmablasts ex vivo and antibody-secreting plasma cells in vivo. These experiments suggest that AhR serves as a molecular rheostat in B cells to brake the effector response, possibly to facilitate optimal recall responses. Thus, AhR might represent a novel molecular target for manipulation of B cell responses during vaccination.

publication date

  • December 23, 2016

Research

keywords

  • B-Lymphocytes
  • Receptors, Aryl Hydrocarbon

Identity

PubMed Central ID

  • PMC5206498

Scopus Document Identifier

  • 85008499447

Digital Object Identifier (DOI)

  • 10.1016/j.it.2015.11.007

PubMed ID

  • 28011866

Additional Document Info

volume

  • 214

issue

  • 1