Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer. uri icon

Overview

abstract

  • The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) is a major nutrient sensor and regulator of cellular metabolic flux. Reporting recently in Nature, Zabala-Letona et al. (2017) show that mTORC1 regulates an additional branch of metabolism in the cell-polyamine synthesis-that is important for prostate cancer tumorigenicity.

publication date

  • July 24, 2017

Research

keywords

  • Multiprotein Complexes
  • TOR Serine-Threonine Kinases

Identity

PubMed Central ID

  • PMC5705022

Scopus Document Identifier

  • 85030533359

Digital Object Identifier (DOI)

  • 10.1016/j.devcel.2017.07.004

PubMed ID

  • 28742999

Additional Document Info

volume

  • 42

issue

  • 2