Reading m6A in the Transcriptome: m6A-Binding Proteins. Review uri icon

Overview

abstract

  • N6-Methyladenosine (m6A) is the most prevalent post-transcriptional modification of eukaryotic mRNA and long noncoding RNA. m6A mediates its effects primarily by recruiting proteins, including the multiprotein eukaryotic initiation factor 3 complex and a set of proteins that contain the YTH domain. Here we describe the mechanisms by which YTH domain-containing proteins bind m6A and influence the fate of m6A-containing RNA in mammalian cells. We discuss the diverse, and occasionally contradictory, functions ascribed to these proteins and the emerging concepts that are influencing our understanding of these proteins and their effects on the epitranscriptome.

publication date

  • November 2, 2017

Research

keywords

  • Adenosine
  • Carrier Proteins
  • Reading Frames
  • Transcriptome

Identity

PubMed Central ID

  • PMC5794650

Scopus Document Identifier

  • 85032941933

Digital Object Identifier (DOI)

  • 10.1101/171827

PubMed ID

  • 29103884

Additional Document Info

volume

  • 28

issue

  • 2