Targeting the Proteostasis Network for Mycobacterial Drug Discovery. Review uri icon

Overview

abstract

  • Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the world's deadliest infectious diseases and urgently requires new antibiotics to treat drug-resistant strains and to decrease the duration of therapy. During infection, Mtb encounters numerous stresses associated with host immunity, including hypoxia, reactive oxygen and nitrogen species, mild acidity, nutrient starvation, and metal sequestration and intoxication. The Mtb proteostasis network, composed of chaperones, proteases, and a eukaryotic-like proteasome, provides protection from stresses and chemistries of host immunity by maintaining the integrity of the mycobacterial proteome. In this Review, we explore the proteostasis network as a noncanonical target for antibacterial drug discovery.

publication date

  • March 2, 2018

Research

keywords

  • Bacterial Proteins
  • Drug Discovery
  • Mycobacterium tuberculosis
  • Proteostasis

Identity

PubMed Central ID

  • PMC5902792

Scopus Document Identifier

  • 85045381703

Digital Object Identifier (DOI)

  • 10.1021/acs.biochem.6b01107

PubMed ID

  • 29465983

Additional Document Info

volume

  • 4

issue

  • 4