Increased analgesic potency of morphine and increased brain opioid binding sites in the rat following chronic naltrexone treatment. Academic Article uri icon

Overview

abstract

  • Implantation of rats with prolonged-release naltrexone pellets increased both morphine's analgesic potency in the tailflick assay and radiolabeled opioid binding in the brain. The increases in both radiolabeled opioid binding and morphine potency were time-dependent. Implantation for 24 hours did not increase binding, whereas increases of approximately 45% were seen following 8 days of implantation. Similarly, morphine's analgesic potency, measured as ED50 values, was increased by 50% following 8 days of exposure to naltrexone while a 24 hour exposure had no significant effect.

publication date

  • June 17, 1985

Research

keywords

  • Brain
  • Morphine
  • Naloxone
  • Naltrexone
  • Pain
  • Receptors, Opioid

Identity

Scopus Document Identifier

  • 0021881089

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(85)90322-4

PubMed ID

  • 2989632

Additional Document Info

volume

  • 36

issue

  • 24