Signaling mechanisms and physiological functions of G-protein Gα<sub>13</sub> in blood vessel formation, bone homeostasis, and cancer.

Overview

Heterotrimeric G-proteins are cellular signal transducers. They mainly relay signals from G-protein-coupled receptors (GPCRs). GPCRs function as guanine nucleotide-exchange factors to active these G-proteins. Based on the sequence and functional similarities, these G-proteins are grouped into four subfamilies: G_s , G_i , G_q , and G_12/13 . The G_12/13 subfamily consists of two members: G₁₂ and G₁₃ . G_12/13 -mediated signaling pathways play pivotal roles in a variety of physiological processes, while aberrant regulation of this pathway has been identified in various human diseases. Here we summarize the signaling mechanisms and physiological functions of Gα₁₃ in blood vessel formation and bone homeostasis. We further discuss the expanding roles of Gα₁₃ in cancers, serving as oncogenes as well as tumor suppressors.