Arachidonic acid releasing systems in pig aorta endothelial cells. Academic Article uri icon

Overview

abstract

  • Endothelial cells synthesize prostacyclin both from platelet-derived endoperoxides and from the arachidonic acid released from its intracellular stores. The mechanisms controlling this release does not appear to be mediated through phospholipid methylation but by means of phosphoinositide hydrolysis. As yet two possible mechanisms have so far been proposed to regulate arachidonic acid release in a number of cellular systems: phospholipase C-controlled phospholipase A2 activity or phospholipase C-diglyceride lipase system. The results presented here show that using phospholipases inhibitors is not a reliable strategy to study arachidonic acid release in cultures of endothelial cells. Our data also strongly suggest that the release of prostacyclin may be accounted in these cells for by a phospholipase C-diglyceride lipase system.

publication date

  • September 30, 1986

Research

keywords

  • Aorta
  • Arachidonic Acids
  • Endothelium

Identity

Scopus Document Identifier

  • 0023010887

Digital Object Identifier (DOI)

  • 10.1016/s0006-291x(86)80290-x

PubMed ID

  • 3094524

Additional Document Info

volume

  • 139

issue

  • 3