Mitogenic activity and inositide metabolism in thrombin-stimulated pig aorta endothelial cells. Academic Article uri icon

Overview

abstract

  • The mitogenic activity of thrombin in endothelial cells is not well understood. The inositide metabolism is an ubiquitous transducing mechanism that seems to be involved in the control of cell growth. Thrombin is a potent stimulant of the release of inositol phosphates in platelets. The data presented here suggest that thrombin is able to induce competence in pig aorta endothelial cells to proliferate in response to insulin. Also thrombin is a potent stimulant of the inositide metabolism what suggests that the activation of this pathway might be at least one of the mechanisms through which thrombin induces competence in this cells.

publication date

  • June 30, 1987

Research

keywords

  • Endothelium
  • Inositol Phosphates
  • Mitogens
  • Sugar Phosphates
  • Thrombin

Identity

Scopus Document Identifier

  • 0023240494

Digital Object Identifier (DOI)

  • 10.1016/0006-291x(87)91579-8

PubMed ID

  • 3111467

Additional Document Info

volume

  • 145

issue

  • 3