Feasibility and clinical value of circulating tumor DNA testing in patients with gastric adenocarcinomas. Academic Article uri icon

Overview

abstract

  • Gastric cancer is one of the leading causes of cancer worldwide, and this trend appears to be rising. Most patients are diagnosed at an advanced stage and thus prognosis is poor. Liquid biopsy, or circulating tumor DNA (ctDNA) testing, is emerging as a promising prognostic and/or predictive biomarker for patients with various types of malignancies. Its value and utility for patients with gastrointestinal malignancies, particularly gastric cancer is still being explored. There is ongoing research in other tumor types to suggest that ctDNA testing can be potentially used to identify tumor specific genomic alterations, predict tumor mutation burden, as well as help assess clinical response. We report on the feasibility and clinical value of ctDNA testing in patients with gastric cancers in a real time clinical context by reporting data on cohort of patients with gastric cancers (including those with gastroesophageal junction adenocarcinomas) treated at our institution.

publication date

  • June 1, 2019

Identity

PubMed Central ID

  • PMC6534707

Scopus Document Identifier

  • 85066945820

Digital Object Identifier (DOI)

  • 10.1200/JCO.2016.34.15_suppl.11534

PubMed ID

  • 31183188

Additional Document Info

volume

  • 10

issue

  • 3