Putrescine, a source of gamma-aminobutyric acid in the adrenal gland of the rat. Academic Article uri icon

Overview

abstract

  • Putrescine is the major source of gamma-aminobutyric acid (GABA) in the rat adrenal gland. Diamine oxidase, and not monoamine oxidase, is essential for GABA formation from putrescine in the adrenal gland. Aminoguanidine, a diamine oxidase inhibitor, decreases the GABA concentration in the adrenal gland by more than 70% after 4 h, and almost to zero in 24 h. Studies using [14C]putrescine confirm that [14C]GABA is the major metabolite of putrescine in the adrenal gland. Inhibition of GABA transaminase by amino-oxyacetic acid does not change the GABA concentration in the adrenal gland, as compared with the brain, where the GABA concentration rises. With aminoguanidine, the turnover time of GABA originating from putrescine in the adrenal gland is 5.6 h, reflecting a slower rate of GABA metabolism compared with the brain. Since GABA in the adrenal gland is almost exclusively derived from putrescine, the role of GABA may relate to the role of putrescine as a growth factor and regulator of cell metabolism.

publication date

  • April 15, 1988

Research

keywords

  • Adrenal Glands
  • Putrescine
  • gamma-Aminobutyric Acid

Identity

PubMed Central ID

  • PMC1149037

Scopus Document Identifier

  • 0023914853

Digital Object Identifier (DOI)

  • 10.1042/bj2510559

PubMed ID

  • 3135801

Additional Document Info

volume

  • 251

issue

  • 2