A pathogenic role of plasmacytoid dendritic cells in autoimmunity and chronic viral infection. Review uri icon

Overview

abstract

  • Following the discovery of plasmacytoid dendritic cells (pDCs) and of their extraordinary ability to produce type I IFNs (IFN-I) in response to TLR7 and TLR9 stimulation, it is assumed that their main function is to participate in the antiviral response. There is increasing evidence suggesting that pDCs and/or IFN-I can also have a detrimental role in a number of inflammatory and autoimmune diseases, in the context of chronic viral infections and in cancers. Whether these cells should be targeted in patients and how much of their biology is connected to IFN-I production remains unclear and is discussed here.

publication date

  • August 16, 2019

Research

keywords

  • Autoimmunity
  • Dendritic Cells
  • Virus Diseases

Identity

PubMed Central ID

  • PMC6719431

Scopus Document Identifier

  • 85071788779

Digital Object Identifier (DOI)

  • 10.1172/JCI89488

PubMed ID

  • 31420375

Additional Document Info

volume

  • 216

issue

  • 9