Barrat, Franck J.

Publications

Sort by

Co-Author Network

selected publications

Role of type I interferons and innate immunity in systemic sclerosis: unbalanced activities on distinct cell types?. Current opinion in rheumatology. 2019 Review GET IT
Times cited: 9
A pathogenic role of plasmacytoid dendritic cells in autoimmunity and chronic viral infection. The Journal of experimental medicine. 2019 Review GET IT
Times cited: 35
Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 48
Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity. Annual review of medicine. 2015 Review GET IT
Times cited: 111
Bruton's tyrosine kinase regulates TLR9 but not TLR7 signaling in human plasmacytoid dendritic cells. European journal of immunology. 2014 Academic Article GET IT
Times cited: 27
RNA recognition by human TLR8 can lead to autoimmune inflammation. The Journal of experimental medicine. 2013 Academic Article GET IT
Times cited: 124
Blocking TLR7- and TLR9-mediated IFN-α production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infection. PLoS pathogens. 2013 Academic Article GET IT
Times cited: 49
Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes. Nature medicine. 2012 Academic Article GET IT
Times cited: 323
Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?. Nature reviews. Immunology. 2011 Review GET IT
Times cited: 108
A novel role of endothelin-1 in linking Toll-like receptor 7-mediated inflammation to fibrosis in congenital heart block. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 57
TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis. Gastroenterology. 2011 Academic Article GET IT
Times cited: 202
Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Science translational medicine. 2011 Academic Article GET IT
Times cited: 990
Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9. The Journal of experimental medicine. 2010 Academic Article GET IT
Times cited: 166
TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus. Nature. 2010 Academic Article GET IT
Times cited: 285
Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block. Journal of immunology (Baltimore, Md. : 1950). 2010 Academic Article GET IT
Times cited: 80
Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. The Journal of experimental medicine. 2009 Academic Article GET IT
Times cited: 536
Signalling pathways leading to IFN-alpha production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications. Journal of internal medicine. 2009 Review GET IT
Times cited: 77
Pathogenic anti-DNA antibodies modulate gene expression in mesangial cells: involvement of HMGB1 in anti-DNA antibody-induced renal injury. Immunology letters. 2008 Academic Article GET IT
Times cited: 66
Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Nature medicine. 2008 Academic Article GET IT
Times cited: 324
Development of TLR inhibitors for the treatment of autoimmune diseases. Immunological reviews. 2008 Review GET IT
Times cited: 155
Strategies for use of IL-10 or its antagonists in human disease. Immunological reviews. 2008 Review GET IT
Times cited: 338
PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. The Journal of experimental medicine. 2008 Academic Article GET IT
Times cited: 191
Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms. European journal of immunology. 2007 Academic Article GET IT
Times cited: 236
Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. The Journal of experimental medicine. 2007 Academic Article GET IT
Times cited: 339
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nature medicine. 2007 Academic Article GET IT
Times cited: 2366
Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis. Blood. 2007 Academic Article GET IT
Times cited: 219
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nature medicine. 2007 Review GET IT
Times cited: 727
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. The Journal of experimental medicine. 2006 Academic Article GET IT
Times cited: 314
Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. The Journal of clinical investigation. 2005 Academic Article GET IT
Times cited: 499
Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses. Immunity. 2005 Academic Article GET IT
Times cited: 237
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. The Journal of experimental medicine. 2005 Academic Article GET IT
Times cited: 769
Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation. Journal of immunology (Baltimore, Md. : 1950). 2005 Academic Article GET IT
Times cited: 110
IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 548
IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences. Blood. 2003 Academic Article GET IT
Times cited: 122
In vitro generation of IL-10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by Th1- and Th2-inducing cytokines. Immunology letters. 2003 Review GET IT
Times cited: 39
In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. The Journal of experimental medicine. 2002 Academic Article GET IT
Times cited: 994
1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. Journal of immunology (Baltimore, Md. : 1950). 2001 Academic Article GET IT
Times cited: 942
A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production. The Journal of experimental medicine. 2001 Academic Article GET IT
Times cited: 122
Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. The Journal of experimental medicine. 2001 Academic Article GET IT
Times cited: 205
Cutting edge: ectopic expression of the IL-12 receptor-beta 2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-gamma. Journal of immunology (Baltimore, Md. : 1950). 2000 Academic Article GET IT
Times cited: 44
Protein truncation test of LYST reveals heterogenous mutations in patients with Chediak-Higashi syndrome. Blood. 2000 Academic Article GET IT
Times cited: 97
Genetic basis of hemophagocytic lymphohistiocytosis syndrome (Review). International journal of molecular medicine. 1999 Review GET IT
Times cited: 61
Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activation. Proceedings of the National Academy of Sciences of the United States of America. 1999 Academic Article GET IT
Times cited: 65
[Genetic defects in control of T cell activation evolving in a syndrome of lymphohistiocytic activation]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. 1999 Academic Article GET IT
Times cited: 3
Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene. Nature genetics. 1997 Academic Article GET IT
Times cited: 367
Identification of mutations in two major mRNA isoforms of the Chediak-Higashi syndrome gene in human and mouse. Human molecular genetics. 1997 Academic Article GET IT
Times cited: 84
Localization of the Rab escort protein-2 (REP2) and inositol 1,4,5-trisphosphate 3-kinase (ITPKB) genes to mouse chromosome 1 by in situ hybridization and precision of the syntenic regions between mouse and human 1q42-q44. Genomics. 1997 Academic Article GET IT
Times cited: 4
Genetic and physical mapping of the Chediak-Higashi syndrome on chromosome 1q42-43. American journal of human genetics. 1996 Academic Article GET IT
Times cited: 84

more ...

less ...

Background

education and training

Ph.D., University of Paris (France) 1998
M.S., University of Paris (France) 1995
B.S., University of Nice (France) 1993

Contact

full name

Franck J. Barrat

primary email

frb3002@med.cornell.edu

VIVO Weill Cornell Medical College

Franck J. Barrat Professor of Microbiology and Immunology

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email