Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma. Academic Article uri icon

Overview

abstract

  • Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer deaths globally. The landscape of systemic therapy has recently changed, with six additional systemic agents either approved or awaiting approval for advanced stage HCC. While these agents have the potential to improve outcomes, a survival increase of 2-5 months remains poor and falls short of what has been achieved in many other solid tumor types. The roles of genomics, underlying cirrhosis, and optimal use of treatment strategies that include radiation, liver transplantation, and surgery remain unanswered. Here, we discuss new treatment opportunities, controversies, and future directions in managing HCC.

authors

publication date

  • September 1, 2019

Research

keywords

  • Carcinoma, Hepatocellular
  • Liver Neoplasms

Identity

PubMed Central ID

  • PMC8330805

Scopus Document Identifier

  • 85071762528

Digital Object Identifier (DOI)

  • 10.1093/annonc/mdy269.057

PubMed ID

  • 31481419

Additional Document Info

volume

  • 79

issue

  • 17