De Novo Pathway-Based Classification of Breast Cancer Subtypes. Academic Article uri icon

Overview

abstract

  • Breast cancer is a heterogeneous disease for which various clinically relevant subtypes have been reported. These subtypes are characterized by molecular differences which direct treatment selection. The state of the art for breast cancer subtyping utilizes histochemistry or gene expression to measure a few selected markers. However, classification based on molecular pathways (rather than individual markers) is a more robust way to classify breast cancer samples into known subtypes.Here, we present PathClass, a web application that allows its users to predict breast cancer subtypes using various traditional as well as advanced methods. This includes methods based on classical gene expression panels as well as de novo pathway-based predictors. Users can predict labels for datasets in the Gene Expression Omnibus or upload their own expression profiling data.Availability: https://pathclass.compbio.sdu.dk/ .

publication date

  • January 1, 2020

Research

keywords

  • Breast Neoplasms

Identity

Scopus Document Identifier

  • 85072911207

Digital Object Identifier (DOI)

  • 10.1007/978-1-4939-9873-9_15

PubMed ID

  • 31583640

Additional Document Info

volume

  • 2074